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Article Abstract
Achieving sustainable catalytic transformations requires synergistic optimization of solvent systems, catalytic motifs and energy inputs. Herein, we report a synergistic Pd/hydroquinone catalytic system that enables aerobic allylic C-H functions under ambient conditions (room temperature to 50°C, air) with high turnover frequency (TOF), using ethanol/water as a green medium. This strategy achieves unparalleled synthetic efficiency and demonstrates remarkable versatility across two pivotal transformations (alkylation and amination) involving over 90 products (up to 96% yield). It also delivers exceptional stereocontrol (up to 93% for quaternary stereocenters) and enables advanced allylic transformations within a green framework through additional synergistic catalysis. By integrating solvent engineering with cooperative catalysis, we have developed a scalable platform for the synthesis of allylic functionalized molecules with pharmaceutical interests, demonstrating how molecule-level innovation can drive sustainable industrial transformation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236312 | PMC |
| http://dx.doi.org/10.1093/nsr/nwaf196 | DOI Listing |
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