Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Mild Behavioral Impairment(MBI) is increasingly recognized as an early phenotypic marker of neurodegeneration, characterized by neuropsychiatric symptoms(NPS) emerging prior to overt cognitive decline. While structural neuroimaging studies link cortical thinning with NPS, the relationship between MBI and cortical morphology remains underexplored in diverse, community-based cohorts. This study investigated whether early behavioral alterations, assessed via the Mild Behavioral Impairment Checklist(MBI-C), correlate with region-specific cortical thinning in a Southeast Asian cohort.
Methods: A cross-sectional analysis was conducted on 969 participants (mean age 61.99±10.19years;39.6% male;87.2%Chinese) from the Biomarkers and Cognition Study in Singapore(BIOCIS), spanning cognitively normal, subjective cognitive decline(SCD), and mild cognitive impairment(MCI). MBI was assessed using self-reported MBI-C. Cortical thickness was measured using T1-weighted MRI scans processed with FreeSurfer. Associations between cortical thinning and MBI-C total and subdomain scores were evaluated.
Results: Higher scores on the MBI-C Belief subdomain were significantly associated with cortical thinning in the right hemisphere(β=-0.0177;95%CI:-0.0342to-0.0012;P=0.035). Region-specific analyses showed temporal lobe thinning in the posterior superior temporal sulcus, fusiform gyrus, superior temporal gyrus, temporal pole, and transverse temporal gyrus, and associations remained significant after false discovery rate(FDR) correction(P=0.042-0.045). Additional cortical thinning was observed in the right postcentral gyrus, supramarginal gyrus, and insula(FDR P≤0.039).
Conclusions: Elevated MBI, particularly abnormal beliefs, is linked to cortical thinning in regions subserving memory, sensory integration, and emotional regulation predominantly in the right hemisphere. These findings highlight the potential of MBI-C as an early neurodegenerative marker. Further longitudinal studies are needed to clarify temporal dynamics and mechanisms underlying behavioral symptoms and neurodegenerative processes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bpsc.2025.06.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Alzheimer's disease (AD) is now defined based on its underlying brain pathology , with the presence of amyloid (Aβ) plaques at high enough levels sufficient to warrant a diagnosis in the absence of cognitive symptoms. High levels of PET-detectable Aβ are widely thought to be the first imaging marker, with structural brain changes detectable on MRI scans thought to occur later. We combined 4570 longitudinal MRIs and 1684 Aβ PET scans from three cognitively healthy cohorts to test the difference in cortical thickness and its change between those that subsequently converted to be Aβ-positive or stayed Aβ-negative, using MRIs acquired exclusively in the years before conversion.
View Article and Find Full Text PDFNeurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson's disease with excessive daytime sleepiness.
Front Aging Neurosci
August 2025
Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Background: Excessive daytime sleepiness (EDS) is a common non-motor symptom in Parkinson's disease (PD) that negatively impacts quality of life. Although biomarkers of brain structure, function, and neurodegeneration have been studied, their interactions in EDS remain unclear. This study explores the relationship between cortical thickness, functional connectivity (FC), and plasma neurofilament light chain (NfL) levels in PD-EDS.
View Article and Find Full Text PDF[Microglia-mediated cognitive impairment induced by methamphetamine].
Nihon Yakurigaku Zasshi
August 2025
Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, University of Toyama.
More than half of chronic methamphetamine (METH) users exhibit multi-domain cognitive deficits, including impaired attention, executive function, and memory. MRI studies consistently demonstrate hippocampal atrophy and frontotemporal cortical thinning; these structural changes spatially overlap with glial activation, indicating the coexistence of morphological damage and ongoing neuroinflammation. To clarify causality, we developed a mouse model in which low-dose METH is micro-infused into the nucleus accumbens.
View Article and Find Full Text PDFSegmental Renal Infarction Associated with Accessory Renal Arteries After Para-Aortic Lymphadenectomy in Gynecologic Malignancies.
Medicina (Kaunas)
August 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan.
: The causes and clinical outcomes of renal perfusion abnormalities occurring after para-aortic lymphadenectomy (PANDx) for gynecologic malignancies are unknown. We investigated the potential involvement of accessory renal artery (ARA) obstruction in their development by reassessing perioperative contrast-enhanced computed tomography (CECT). : This retrospective study investigated a clinical database to identify urinary contrast defects using CECT in all patients who had undergone PANDx between January 2020 and December 2024.
View Article and Find Full Text PDFMissense Variant in Dogs with Cerebellar Ataxia.
Genes (Basel)
August 2025
Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Hereditary ataxias are a highly heterogenous group of diseases characterized by loss of coordination. In this study, we investigated a family of random-bred dogs, in which two siblings were affected by a slowly progressive ataxia. They presented with clinical signs of progressive cerebellar ataxia, hypermetria, and absent menace response.
View Article and Find Full Text PDF