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The Life Detection Knowledge Base (LDKB) is a community webtool developed to test and evaluate strategies to search for evidence of life beyond Earth, with an emphasis on recognizing potential false-positive and false-negative results. As part of the LDKB framework, we developed a taxonomy of potential biosignatures. The taxonomy brings together a broad array of life-detection strategies into a common and systematic structure that allows for equitable evaluations based on a specific set of criteria, chosen to assess the likelihood of false-positive and false-negative interpretations. The taxonomy is also a tool to organize life-detection strategies in a way that streamlines their infusion into robotic spaceflight missions. This article describes the structure of the taxonomy and its functional qualities. Two accompanying articles detail the overall LDKB framework and the set of criteria used to evaluate potential biosignatures.
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http://dx.doi.org/10.1089/ast.2022.0156 | DOI Listing |
Astrobiology
September 2025
Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
Concentrated magnesium chloride brines are extreme environments that are inhospitable to life on Earth. The ionic strength of these brines significantly depresses water activity and concomitantly exerts significant chaotropic stress. Although these brines are largely considered sterile, the well-known preservative effects of magnesium chloride on certain biomolecules, such as DNA, confound life detection approaches and efforts to constrain precisely the habitable window of life on Earth.
View Article and Find Full Text PDFArterioscler Thromb Vasc Biol
September 2025
Department of Medicine, Center for the Prevention of Cardiovascular Disease, New York University School of Medicine. (M.S.G., J.S.B.).
Background: The underlying mechanisms of atherosclerosis and strategies for identifying high cardiovascular risk in psoriasis are incompletely understood. Platelet activity is increased in psoriasis and induces vascular dysfunction. We investigated the platelet phenotype and platelet transcriptome as one potential mechanism to explain cardiovascular risk in psoriasis.
View Article and Find Full Text PDFClin Transl Gastroenterol
September 2025
Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
Background: Gastric cancer (GC) is a lethal malignant tumor necessitating high-sensitivity detection to improve diagnostic accuracy and the prognosis of patients. Alterations in long noncoding RNAs can influence cancer progression through various mechanisms. Our study tried to explore the potential of STARD4-AS1 as a GC biomarker and its mechanism of action in GC development.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
August 2025
Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, Spain; Área del Corazón, Hospital Universitario Virgen de la Victoria, Málaga, Spain; CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain;
Cocaine disrupts neurotransmitter systems and promotes neuroinflammation by activating microglia and altering cytokine signaling. The CXCL1/CXCR1 axis is an essential signaling pathway for microglial regulation, may exhibit sex-specific responses to cocaine. In this study, male and female Wistar rats were exposed to acute (5, 15, or 30 mg/kg) or repeated (15 mg/kg/day for two weeks) cocaine.
View Article and Find Full Text PDFMicroorganisms
August 2025
LAMIR Institute, Graduate Program in Geology, Universidade Federal do Paraná, Curitiba 81531-980, Paraná, Brazil.
Extreme environments, such as hypersaline habitats, hot springs, deep-sea hydrothermal vents, glaciers, and permafrost, provide diverse ecological niches for studying microbial evolution. However, knowledge of microbial communities in extreme environments at high southern latitudes remains limited, aside from Antarctica. Laguna Timone is a hypersaline crater lake located in a Pleistocene maar of the Pali Aike Volcanic Field, southern Patagonia; the lake was formed during basaltic eruptions in a periglacial setting.
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