98%
921
2 minutes
20
Model-based clustering is a powerful approach used in data analysis to unveil underlying patterns or groups within a data set. However, when applied to clusters that exhibit skewness, heavy tails, or both, the classification of data points becomes more challenging. In this study, we introduce two models considering two component-wise transformations of the observed data within a mixture of multiple scaled contaminated normal (MSCN) distributions. MSCN distributions are designed to enable a different tail behavior in each dimension and directional outlier detection in the direction of the principal components. Using the transformed MSCN distributions as components of a mixture, we obtain model-based clustering techniques that allow for 1) flexible cluster shapes in terms of skewness and kurtosis and 2) component-wise and directional outlier detection. We assess the efficacy of the proposed techniques by comparing them with model-based clustering methods that perform global or component-wise outlier detection using simulated and real data sets. This comparative analysis aims to demonstrate which practical clustering scenarios using the proposed MSCN-based approaches are advantageous.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226708 | PMC |
http://dx.doi.org/10.1007/s00362-025-01723-9 | DOI Listing |
PLoS One
September 2025
Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Student dropout is a significant challenge in Bangladesh, with serious impacts on both educational and socio-economic outcomes. This study investigates the factors influencing school dropout among students aged 6-24 years, employing data from the 2019 Multiple Indicator Cluster Survey (MICS). The research integrates statistical analysis with machine learning (ML) techniques and explainable AI (XAI) to identify key predictors and enhance model interpretability.
View Article and Find Full Text PDFMar Life Sci Technol
August 2025
Department of Marine Sciences, University of Puerto Rico at Mayagüez, P.O. Box 9000, Mayagüez, PR 00681 USA.
Unlabelled: The queen snapper ( Valenciennes in Cuvier & Valenciennes, 1828) is a deep-sea snapper whose commercial importance continues to increase in the US Caribbean. However, little is known about the biology and ecology of this species. In this study, the presence of a fine-scale population structure and genetic diversity of queen snapper from Puerto Rico was assessed through 16,188 SNPs derived from the Restriction site Associated DNA Sequencing (RAD-Seq) technique.
View Article and Find Full Text PDFOncol Res
September 2025
Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Studies have reported the special value of PANoptosis in cancer, but there is no study on the prognostic and therapeutic effects of PANoptosis in bladder cancer (BLCA). This study aimed to explore the role of PANoptosis in BLCA heterogeneity and its impact on clinical outcomes and immunotherapy response while establishing a robust prognostic model based on PANoptosis-related features. Gene expression profiles and clinical data were collected from public databases.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Clinical Laboratory, Eighth Affiliated Hospital of Guangxi Medical University, Guigang City People's Hospital, Guigang, Guangxi, China.
Background: Hepatocellular carcinoma (HCC) prognosis continues to be challenging due to tumor heterogeneity and dynamic immunosuppressive microenvironments. Although pyroptosis plays a critical role in tumor-immune interactions, its prognostic significance in HCC at single-cell resolution has not been systematically investigated.
Methods: We analyzed a publicly available single-cell RNA sequencing (scRNA-seq) data from 10 HCC tumors and paired adjacent tissue samples (60,496 cells) to elucidate pyroptosis-related gene (PRG) profiles.
Nan Fang Yi Ke Da Xue Xue Bao
August 2025
Department of Urology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510000, China.
Objectives: To identify immunosuppressive neutrophil subsets in patients with prostate cancer (PCa) and construct a risk prediction model for prognosis and immunotherapy response of the patients based on these neutrophil subsets.
Methods: Single-cell and transcriptome data from PCa patients were collected from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). Neutrophil subsets in PCa were identified through unsupervised clustering, and their biological functions and effects on immune regulation were analyzed by functional enrichment, cell interaction, and pseudo-time series analyses.