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Objective: To investigate the status of postoperative loneliness and factors influencing it in elderly patients with breast cancer.
Methods: The questionnaire survey was conducted between 1 January 2022 and 31 October 2024 in our hospital to screen 229 elderly patients with breast cancer after surgery who met the inclusion criteria. The patients' general information was collected, and their General Alienation Scale, Fear of Disease Progression Scale (short form; FoP-Q-SF), 10-item Connor-Davidson Resilience Scale (CD-RISC10), Social Support Scale (PSSS), Social Constraints Scale (SCS) and General Self-Efficacy Scale (GSES) scores were compared.
Results: Univariate analysis showed that the differences in social detachment scores among patients of different age groups, marital status, education level, per capita monthly income and surgical modality and whether or not they were receiving chemotherapy were significant (p < 0.001). Multifactorial analysis showed that age group, marital status, surgical modality and chemotherapy as well as their FoP-Q-SF, CD-RISC10, PSSS and SCS scores were all associated with loneliness in elderly patients with breast cancer. Structural equation modelling showed that social support (p < 0.001) and mental toughness (p < 0.001) negatively predicted social alienation, and social constraints (p < 0.001) and fear of disease progression (p < 0.001) positively predicted social alienation. Moreover, mental toughness (p < 0.001) and social support (p < 0.001) negatively predicted fear of disease progression. Social constraints negatively influenced mental toughness (p < 0.001), and social support positively influenced mental toughness (p < 0.001).
Conclusion: Loneliness in elderly patients with breast cancer is at a moderate level and needs to be improved by further research. Mental toughness, fear of disease progression, a history of chemotherapy and social constraints are influential factors in loneliness.
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http://dx.doi.org/10.1111/jep.70177 | DOI Listing |
JAMA Netw Open
September 2025
Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Lübeck, Lübeck, Germany.
Importance: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress; however, access to psychological support remains limited.
Objective: To investigate the effectiveness of a digital psychological intervention for individuals with IRDs.
Design, Setting, And Participants: Participants aged 18 years or older were recruited across Germany between February 22 and June 4, 2024, if they had been diagnosed with rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus and reported psychological distress and reduced quality of life.
JAMA Netw Open
September 2025
Division of Cardiology, Duke University Hospital, Durham, North Carolina.
Importance: Previous data suggest that the time changes associated with daylight savings time (DST) may be associated with an increased incidence of acute myocardial infarction (AMI).
Objective: To determine whether the incidence of patients presenting with AMI is greater during the weeks during or after DST and compare the in-hospital clinical events between the week before DST and after DST.
Design, Setting, And Participants: This cross-sectional study examined patients enrolled in the Chest Pain MI Registry from 2013 to 2022.
JAMA Netw Open
September 2025
Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Importance: As obesity rates rise in the US, managing associated metabolic comorbidities presents a growing burden to the health care system. While bariatric surgery has shown promise in mitigating established metabolic conditions, no large studies have quantified the risk of developing major obesity-related comorbidities after bariatric surgery.
Objective: To identify common metabolic phenotypes for patients eligible for bariatric surgery and to estimate crude and adjusted incidence rates of additional metabolic comorbidities associated with bariatric surgery compared with weight management program (WMP) alone.
JAMA Netw Open
September 2025
Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Importance: Patients with advanced cancer frequently receive broad-spectrum antibiotics, but changing use patterns across the end-of-life trajectory remain poorly understood.
Objective: To describe the patterns of broad-spectrum antibiotic use across defined end-of-life intervals in patients with advanced cancer.
Design, Setting, And Participants: This nationwide, population-based, retrospective cohort study used data from the South Korean National Health Insurance Service database to examine broad-spectrum antibiotic use among patients with advanced cancer who died between July 1, 2002, and December 31, 2021.
JAMA Netw Open
September 2025
Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.
Importance: Advances in diagnostics have enabled the detection of more gastrointestinal pathogens, but misuse of diagnostics can lead to inappropriate antibiotic use and excess financial burdens. Ensuring appropriate use of diagnostics is crucial for optimizing patient care and promoting stewardship of health care resources.
Objective: To elicit parents' and clinicians' perspectives on expectations for care of pediatric diarrhea with a focus on diagnostic testing and to evaluate the potential for an electronic clinical decision support tool (ECDST) to improve appropriate use of diagnostics.