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The supramolecular fluorescent probe exhibited promising application in the field of detection and analysis, but developing supramolecular fluorescent probes with long wavelength emission and enhancement functions for the detection of phenylethylamines is a challenge. In this work, the guest molecule SPn with a D-π-A structure was designed and synthesized, and supramolecular fluorescent probe (SPn/Q[8]) with long wavelength emission was constructed by the host-guest interaction with cucurbit[8]uril (Q[8]). This probe detects phenethylamines based on an indicator displacement assay, which is a process characterized by a fast effect rate (within 6.24 s), high selectivity, and low detection limit. In addition, a smartphone-based quantitative detection system was developed for trace detection of phenethylamine, with a detection limit of 2.35 μM. This research not only developed a new approach for supramolecular fluorescent probes, but also provided a useful tool for the on-site detection of phenylethylamine.
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http://dx.doi.org/10.1016/j.saa.2025.126555 | DOI Listing |
ACS Macro Lett
September 2025
Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Sulfone bonding is an emerging dipole-dipole interaction between sulfone groups. Herein, sulfone bonding is used for the first time for engineering tough hydrogels. Sulfone-bond-toughened hydrogels are prepared by copolymerizing acrylamide with a sulfone-functionalized monomer.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven 5600 MB, The Netherlands.
Multivalent binding and the resulting dynamical clustering of receptors and ligands are known to be key features in biological interactions. For optimizing biomaterials capable of similar dynamical features, it is essential to understand the first step of these interactions, namely the multivalent molecular recognition between ligands and cell receptors. Here, we present the reciprocal cooperation between dynamic ligands in supramolecular polymers and dynamic receptors in model cell membranes, determining molecular recognition and multivalent binding via receptor clustering.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
Department of Breast Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, PR China. Electronic address:
Background: Breast-conserving surgery (BCS) is the primary surgical approach for patients with breast cancer. The accurate determination of surgical margins during BCS is critical for patient prognosis; however, time constraints and limitations in current pathological techniques often prevent pathologists from performing this assessment intraoperatively. The inability to reliably assess margins during surgery can lead to incomplete tumor removal and the need for additional surgeries.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Chemical Sciences, Ariel University, 70400, Israel. Electronic address:
Doubly His-tagged mCherry red fluorescent proteins are observed to form fibers and sheets at neutral pH in the presence of no more than equimolar amounts of Zn or Ni. These architectures, on the order of 10 μm in extent, are detected with scanning transmission electron microscopy imaging. Far ultraviolet circular dichroism spectroscopy attests to the preservation of the native secondary structure of mCherry, while the emission spectrum reveals the maintenance of the chemical environment of the fluorophore site.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
State Key Laboratory of Advanced Materials for Intelligent Sensing and Key Laboratory of Organic Integrated Circuits, Ministry of Education & Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Institute of Molecular Plus, Department of Chemistry, Tianjin University, Tianjin 300072, China.
Incorporating boron atoms into organic macrocycles imparts unique chemical, electronic, and optical properties. The concept of making use of dative boron-nitrogen (B ← N) bonds for the construction of macrocycles has been proposed, but very few examples have been prepared with functional structures, much less pillar-like and other prismatic macrocycles, and their various functionalities have not been fully exploited. Here, we introduce a "functional molecular wall" synthetic protocol based on the self-assembly characteristics of B ← N dative bonds to construct highly symmetrical macrocycles, forming a quasi-pentagonal-shaped macrocycle (named [5]pyBN-) with a pillar-like structure.
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