A turn-on supramolecular probe for visible detection and accurate identification of phenethylamine with orange emission.

Spectrochim Acta A Mol Biomol Spectrosc

Guizhou Key Laboratory of Macrocyclic and Supramolecular Chemistry, School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China. Electronic address:

Published: January 2026


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Article Abstract

The supramolecular fluorescent probe exhibited promising application in the field of detection and analysis, but developing supramolecular fluorescent probes with long wavelength emission and enhancement functions for the detection of phenylethylamines is a challenge. In this work, the guest molecule SPn with a D-π-A structure was designed and synthesized, and supramolecular fluorescent probe (SPn/Q[8]) with long wavelength emission was constructed by the host-guest interaction with cucurbit[8]uril (Q[8]). This probe detects phenethylamines based on an indicator displacement assay, which is a process characterized by a fast effect rate (within 6.24 s), high selectivity, and low detection limit. In addition, a smartphone-based quantitative detection system was developed for trace detection of phenethylamine, with a detection limit of 2.35 μM. This research not only developed a new approach for supramolecular fluorescent probes, but also provided a useful tool for the on-site detection of phenylethylamine.

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http://dx.doi.org/10.1016/j.saa.2025.126555DOI Listing

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