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This review explores the perspectives of Indigenous young people aged 10 to 24 on programs aimed at preventing chronic diseases, which are prevalent among Indigenous populations and tend to increase with age. This study synthesizes findings from 13 qualitative studies conducted across Canada, Australia, New Zealand, and the United States, involving 441 participants. The analysis identified four key themes. First, safeguarding food sovereignty emerged as a foundational priority, emphasizing access to traditional foods, nutritional needs, and food security. Second, empowering emerging leaders through the transfer of traditional wisdom and knowledge was recognized as vital for fostering agency and influence within communities. Third, strengthening the sociocultural fabric involved promoting community inclusion, securing community buy-in, and emphasizing the importance of elders and family involvement, alongside integrating cultural practices into health initiatives. Fourth, navigating challenges such as disengagement due to limited health knowledge and ambiguity surrounding health trajectories highlighted barriers that need addressing. The findings suggest that effective programs should involve family members, build community capacity, and foster leadership among Indigenous youth. Culturally appropriate community-developed interventions that actively engage Indigenous youth are essential for meaningful impact. This study highlights the importance of partnership with Indigenous communities to develop tailored programs that respect cultural practices and address specific needs, ultimately aiming to reduce the disproportionate burden of chronic disease in Indigenous populations through culturally sensitive youth-centered approaches.
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http://dx.doi.org/10.1016/j.jadohealth.2025.04.005 | DOI Listing |
Biochem Biophys Res Commun
September 2025
Department of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, China; Institute of Vascular Diseases, Central South University, Changsha, 410011, China. Electronic address:
Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular condition that currently lacks effective pharmacological treatment. The disease is strongly associated with chronic inflammation, where immune cells like macrophages play a crucial role. Efferocytosis, the process by which apoptotic cells are cleared, is involved in regulating inflammation.
View Article and Find Full Text PDFInjury
September 2025
Washington University School of Medicine, Department of Orthopaedic Surgery, St. Louis, MO, USA. Electronic address:
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for Type 2 diabetes and obesity due to their cardiometabolic benefits. However, their effects on fracture healing remain controversial. This study investigates perioperative GLP-1 RA use and outcomes following surgical treatment of lower extremity (LE) fractures.
View Article and Find Full Text PDFDiabetes Metab Res Rev
September 2025
Department of Nephrology, Daping Hospital, Army Medical University, Chongqing, China.
Chronic kidney disease (CKD) substantially increases cardiovascular risk, with endothelial dysfunction as its central pathological mechanism. This review summarises the molecular regulatory mechanisms underlying endothelial dysfunction in CKD and highlights recent advances in treatment strategies. The pathophysiology of endothelial injuries involves a complex network of multiple factors and mechanisms, including oxidative stress, inflammation, glycocalyx damage, ischaemia, hypoxia, cellular senescence and endothelial-mesenchymal transition (EndMT).
View Article and Find Full Text PDFAm J Reprod Immunol
September 2025
Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Objective: Exosomes are secreted by most cell types and reflect the internal state of their cells of origin, playing crucial roles in the progression of various pathological conditions. Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by the ectopic presence of endometrial-like tissue outside the uterus, including in the ovaries, fallopian tubes, and peritoneal cavity. It primarily affects women of reproductive age and is often associated with infertility.
View Article and Find Full Text PDFInflamm Bowel Dis
September 2025
Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Background: Intestinal cells receive incoming signals from neighboring cells and microbial communities. Upstream signaling pathways transduce these signals to reach transcription factors (TFs) that regulate gene expression. In inflammatory bowel disease (IBD), most single nucleotide polymorphisms (SNPs) are in non-coding genomic regions containing TF binding sites.
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