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Quantitative analysis of coproporphyrin and its precursors as endogenous biomarkers for drug-drug interactions involving OATP1B1 and OATP1B3 in monkeys.
Drug Metab Dispos
August 2025
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. Electronic address:
Coproporphyrin (CP)-I has emerged as a promising endogenous biomarker for investigating organic anion transporting polypeptide (OATP) 1B1/1B3-mediated drug-drug interactions. The precursor eliminated analytical (PEA) method selectively quantifies the endogenous CP-I that should be monitored, whereas the precursor oxidized analytical method quantifies the total CP-I concentration by converting all precursors into CP-I during the sample preparation process. Plasma concentrations of CP-I exhibited a greater magnitude of change in response to rifampicin treatment compared with its precursor in a previous monkey study.
View Article and Find Full Text PDFAntituberculosis drug-induced hypersensitivity: clinical characteristics and risk factors.
Allergol Immunopathol (Madr)
September 2025
Department of Allergy and Immunology, University of Health Sciences, Süreyyapaşa Training and Research Hospital, Istanbul, Turkey.
Background: Antituberculosis drugs can cause hypersensitivity reactions that interrupt treatment and increase morbidity. Early identification and management are essential to prevent complications and drug resistance.
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[Debridement, antimicrobial therapy, and implant retention for acute periprosthetic infections].
Orthopadie (Heidelb)
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Technische Universität München, Klinikum rechts der Isar, Klinik und Poliklinik für Orthopädie und Sportorthopädie, Ismaninger Str. 22, 81675, München, Deutschland.
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View Article and Find Full Text PDFRisk factors and leprosy incidence among contacts in Bangladesh: A multilevel analysis.
PLoS Negl Trop Dis
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Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
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View Article and Find Full Text PDFEffect of smoking on drug-resistant tuberculosis treatment outcomes and exploring potential pathways: A multicountry cohort study.
medRxiv
August 2025
Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
People who smoke are at increased risk of unfavorable tuberculosis (TB) treatment outcomes compared with those who do not, but the pathways explaining this effect are unclear. We estimated the effect of smoking on a successful end-of-treatment outcome for multidrug-resistant and rifampicin-resistant (MDR/RR) TB and examined if intervening on loss to follow-up mitigates this effect. The endTB Observational Study was a prospective cohort of people with MDR/RR-TB who were treated with longer regimens containing bedaquiline and/or delamanid.
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