Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cmi.2025.06.030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PBDE Flame Retardant Exposure Causes Neurobehavioral and Transcriptional Effects in First-Generation but Not Second-Generation Offspring Fish.
Environ Sci Technol
September 2025
Department of Environmental Toxicology, University of California Davis, Davis, California 95616, United States.
Pollution can have lasting effects beyond the exposure period, potentially impacting multiple generations. Polybrominated diphenyl ether (PBDE) flame retardants are widespread, including in oceans, yet their multigenerational impacts remain poorly understood. We investigated whether BDE-99, a ubiquitous PBDE, induces neurobehavioral and molecular effects across generations in the fish .
View Article and Find Full Text PDFAndrogen therapy in midlife and older women: a position statement of the Latin American Association of Gynecological Endocrinology (ALEG).
Climacteric
September 2025
Escuela de Postgrado en Salud, Universidad Espíritu Santo, Samborondón, Ecuador.
Objective: Androgens have been prescribed to alleviate symptoms in midlife women, but evidence regarding benefits and risks remains limited, with no clearly established indications for Testosterone therapy. In many Latin American countries, Testosterone is prescribed without specific guidelines, making it difficult to identify patients who might benefit. This position statement aims to summarize evidence and provide a Latin American perspective on androgen therapy in midlife and older women.
View Article and Find Full Text PDFSafety and Efficacy of Dexmedetomidine in Spinal Fusion: A Systematic Review and Meta-Analysis Dexmedetomidine in Spinal Fusion Surgery.
J Pain Palliat Care Pharmacother
September 2025
Spine Unit, Orthopaedic Surgery and Traumatology Department, Catholic University and Polytechnic Hospital, Valencia, Spain.
Dexmedetomidine (DEX) has been proposed as an opioid-sparing adjunct after spinal fusion, but its efficacy across age groups is unclear. We conducted a systematic review and meta-analysis following PRISMA and registered in International Prospective Register of Systematic Reviews (PROSPERO) (CRD42024531252). Twelve studies (RCTs and cohorts; n=1,644) were included.
View Article and Find Full Text PDFCurcumin enhances the oral bioavailability of testosterone by inhibiting its intestinal metabolism.
Drug Metab Dispos
August 2025
Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:
Hypogonadism, characterized by low testosterone blood levels, affects 3%-5% of males worldwide. Oral testosterone undecanoate (TU) is emerging as a key route of administration due to its better ease of administration; however, it suffers from variable pharmacokinetics and pharmacodynamics. The variability is majorly attributed to intestinal glucuronidation of testosterone to its hydrophilic metabolite, testosterone glucuronide (TG), formed by the polymorphic uridine 5'-diphospho-glucuronosyltransferase 2B17 (UGT2B17).
View Article and Find Full Text PDFConstructing the optimal experimental autoimmune thyroiditis mouse model using porcine thyroglobulin.
Front Immunol
September 2025
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Introduction: Autoimmune thyroiditis (AIT) is a chronic autoimmune disease characterized by lymphocytic infiltration of the thyroid gland and elevated specific antibodies. Its incidence rises annually, yet no standardized animal model fully mimics human AIT. Given unclear pathogenesis and lack of targeted immunotherapies, researchers invest significant time in developing suitable models.
View Article and Find Full Text PDF