Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Two-level systems based on point defects in dielectric oxides offer promising entropy source for random number generators. The random telegraph noise (RTN) generated by the two-level systems is ideal for creating random bit-strings for advanced computing and cryptographic technologies. However, in classical oxide systems, RTN signals often suffer from instability due to undesired defect migration and metastable electronic states. Herein, we present a two-level quantum system based on SrRuO/LaAlO/Nb-doped SrTiO heterostructure, which incorporates two different types of point defects, oxygen vacancies and antisite Ti defects. Temporal electron localization at antisite defects alters the energy levels of nearby oxygen vacancies through instantaneous Coulomb interaction, resulting in two-level current fluctuation across the interface. The RTN-like current signals exhibit high stability at room temperature. We utilize the stable two-level fluctuations to generate random bit-strings and confirm their applicability in practical stochastic machine learning algorithms for image super-resolution. This study provides a guideline for designing reliable entropy sources by exploiting the complementary interactions between cation and anion point defects in oxide-based electronic systems, essential for hardware-based random number generators.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214674PMC
http://dx.doi.org/10.1038/s41467-025-60672-xDOI Listing

Publication Analysis

Top Keywords

point defects
12
stable two-level
8
two-level current
8
current fluctuation
8
two-level systems
8
random number
8
number generators
8
random bit-strings
8
oxygen vacancies
8
antisite defects
8

Similar Publications

Introduction: Primary central nervous system vasculitis (primary CNS vasculitis) is a rare inflammatory disorder that affects small-to-medium-sized cerebral vessels, often leading to recurrent strokes. Diagnosis is vague due to non-specific neurological symptoms. Imaging findings, cerebrospinal fluid (CSF) analysis and exclusion of systemic vasculitis are essential for diagnosis.

View Article and Find Full Text PDF

Brugada ECG Pattern in A Caucasian Patient with Severe Hypothyroidism.

Eur J Case Rep Intern Med

August 2025

Internal Medicine and Hypertension Center, Sant'Anna Hospital Castelnovo ne' monti, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Unlabelled: Brugada syndrome (BrS) is a disorder leading to potentially life-threatening ventricular arrhythmias in patients with an apparently normal heart. It mostly affects men of Asian descent, and the prevalence varies between ethnicities. Typical ECG abnormalities with no symptoms are referred to as the Brugada pattern, and hypothyroidism is a potential trigger of this.

View Article and Find Full Text PDF

Unlabelled: Encephalitis is a potentially life-threatening condition with infectious or autoimmune aetiologies. Autoimmune encephalitis includes paraneoplastic variants associated with specific onconeural antibodies such as anti-Hu, frequently linked to malignancies. Herpes simplex virus type 1 (HSV-1) is the leading infectious cause in adults.

View Article and Find Full Text PDF

Background: Blinatumomab and inotuzumab ozogamicin (InO) are B-cell targeted agents used in the frontline and relapsed/refractory treatment of B-cell acute lymphoblastic leukaemia (B-ALL). Blinatumomab, a bispecific T-cell engager that targets CD19 and CD3, and InO, an antibody-drug conjugate targeting CD22, have both shown efficacy. However, recent reports have noted lineage conversion as a complication when these agents are used individually or sequentially.

View Article and Find Full Text PDF

Background: Bone marrow (BM) Measurable Residual Disease (MRD) assessments underestimate disease burden in multiple myeloma, as focal lesions can exist outside the marrow. Functional imaging, like positron emission tomography-computed tomography (PET-CT), offers valuable insights into residual disease beyond the marrow. Combining marrow flow cytometry (FCM) with PET-CT for a composite MRD (cMRD) assessment before and after autologous stem cell transplant (ASCT) is expected to provide prognostic information, particularly in settings where patients receive extended duration of anti-myeloma therapy prior to ASCT.

View Article and Find Full Text PDF