Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The complement system, a vital component of innate immunity, is indispensable to our immune defence mechanisms against microbial infections. Acting as a surveillance mechanism, it identifies and eliminates pathogens by activating several complement components and associated signalling pathways, which are also implicated in various diseases and disorders. Beyond its defensive role, the complement system has emerged as a promising target for vaccine development in therapeutic and preventive regimens, offering new vaccine strategies to combat non-infectious and infectious diseases. Activation of the complement pathways by various natural and synthetic adjuvants enhances protective immune responses, highlighting its utility in vaccine design. This approach could be useful for targeting autoimmune diseases, infectious diseases, cancer and neurological disorders.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212990 | PMC |
| http://dx.doi.org/10.1098/rsif.2025.0138 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chronic treatment with fluoxetine regulates mitochondrial features and plasticity-associated transcriptomic pathways in parvalbumin-positive interneurons of prefrontal cortex.
Neuropsychopharmacology
September 2025
Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.
Chronic treatment with fluoxetine, a widely prescribed selective serotonin reuptake inhibitor (SSRI), is known to promote neural plasticity. The role of fluoxetine in plasticity has been particularly tied to parvalbumin-positive interneurons, a key population of GABAergic neurons that regulate inhibitory tone and network stability. While our previous studies have highlighted fluoxetine-induced plasticity in the visual cortex and hippocampus, its cell-type-specific effects in the prefrontal cortex (PFC) remain unclear.
View Article and Find Full Text PDFThe arabidopsis WAVE/SCAR protein BRICK1 associates with cell edges and plasmodesmata.
PLoS One
September 2025
Department of Biology, The University of Saskatchewan, College of Arts and Science, Saskatoon, Canada.
Plasmodesmata are specialized structures in plant cell walls that mediate intercellular communication by regulating the trafficking of molecules between adjacent cells. The actin cytoskeleton plays a pivotal role in controlling plasmodesmatal permeability, but the molecular mechanisms underlying this regulation remain unclear. Here, we report that BRK1, a component of the WAVE/SCAR complex involved in Arp2/3-mediated actin nucleation, localizes to PD and primary pit fields in A.
View Article and Find Full Text PDFGacA regulates symbiosis and mediates lifestyle transitions in .
mSphere
September 2025
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Through horizontal gene transfer, closely related bacterial strains assimilate distinct sets of genes, resulting in significantly varied lifestyles. However, it remains unclear how strains properly regulate horizontally transferred virulence genes. We hypothesized that strains may use components of the core genome to regulate diverse horizontally acquired genes.
View Article and Find Full Text PDFPathotype-Specific Expression of Granzyme-Perforin Pathway Genes and Their Association With Clinical Disease Activity in Early Rheumatoid Arthritis and in a Randomized Clinical Trial.
Immune Netw
August 2025
Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Rheumatoid arthritis (RA) is an autoimmune disease. We examined gene expression of five granzymes (GZMs), perforin (PRF-1), and serglycin (SRGN) from tissues derived from pathobiology of early arthritis cohort (PEAC) and phase 4 randomized controlled trial in anti-TNF inadequate responder patients with RA (R4RA). Information regarding gene expression of , , and in synovium and blood pathotypes and their correlations with disease activity scores with 28 joints (DAS28)-erythrocyte sedimentation rate and with DAS28-C-reactive protein in early RA (eRA) is lacking.
View Article and Find Full Text PDFImplementation and evaluation of a family planning intervention engaging mothers-in-law of young women in India: a mixed methods pilot study.
Glob Health Action
December 2025
Institute for Global Health Sciences, University of California, San Francisco, CA, USA.
Background: Despite evidence that mothers-in-law (MILs) influence daughters-in-law's (DILs) fertility and family planning decisions in South Asia, emphasizing early fertility and male grandchildren, few reproductive health interventions engage MILs directly.
Objectives: We assessed the feasibility, acceptability, and qualitative impact of a reproductive health and life skill-based intervention on MILs in tribal Rajasthan, India, using a mixed-methods, single-group cluster pilot study.
Methods: We tested a light-touch four-session intervention delivered over 4 months to MILs of newly married women that covered MILs' health, conception, and communication with DILs and sons and addressed modern healthcare misconceptions, while challenging son preference and fertility norms.