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Introduction: Prefrailty is common among community-dwelling older adults with diabetes and can lead to adverse health outcomes. With effective exercise interventions, prefrailty is reversible. However, there is a paucity of evidence regarding the effects of exercise interventions for prefrail older adults with diabetes. This study presents a study protocol for evaluating the effectiveness of an exercise intervention based on the Capacity, Opportunity and Motivation Behaviour (COM-B) model among community-dwelling prefrail older adults with diabetes.
Methods And Analysis: Using a randomised controlled trial design, a total of 100 community-dwelling prefrail older adults with diabetes will be allocated to either an intervention or a control group in a 1:1 ratio. Participants in the intervention group will receive a 16-week multicomponent exercise intervention based on the COM-B model, while those in the control group will receive usual diabetes care and general advice on physical activity. The primary outcome is frailty status, and the secondary outcomes include physical function, quality of life, depressive symptoms, self-efficacy for exercise and fasting blood glucose. Assessments will be conducted at baseline, week 8 and week 16.
Ethics And Dissemination: This study has been approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University (approval number: K2023-320). The findings will be submitted to a peer-reviewed journal for publication.
Trial Registration Number: ChiCTR2400082831.
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http://dx.doi.org/10.1136/bmjopen-2025-098945 | DOI Listing |
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Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
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View Article and Find Full Text PDFHum Brain Mapp
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Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Perinatal stroke is a vascular injury occurring early in life, often resulting in motor deficits (hemiplegic cerebral palsy/HCP). Comorbidities may also include poor neuropsychological outcomes, such as deficits in memory. Previous studies have used resting state functional MRI (fMRI) to demonstrate that functional connectivity (FC) within hippocampal circuits is associated with memory function in typically developing controls (TDC) and in adults after stroke, but this is unexplored in perinatal stroke.
View Article and Find Full Text PDFNeuropsychol Dev Cogn B Aging Neuropsychol Cogn
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Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Cognitive function is a critical health indicator of older adults in later life. However, previous research has paid less attention to the impact of pre-retirement work-related characteristics on cognitive functions, especially in Asia. Thus, this study aims to examine the relationship between work-related factors and cognitive functions of the retired population, using Taiwan as an example.
View Article and Find Full Text PDFAnn Geriatr Med Res
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Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
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Foot Ankle Int
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Department of Radiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
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