Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: This study investigates the link between ubiquitin-specific peptidase 9 X-linked (USP9X) and Alzheimer's disease (AD) pathogenesis, aiming to identify potential targets for AD diagnosis, treatment, and drug development.
Methods: We constructed a USP9X-inhibited expression mouse model and assessed cognitive and memory functions. We also measured Tau phosphorylation and APP levels in the hippocampal dentate gyrus (DG) and analyzed neuronal functions, dendritic spine features, late apoptosis, and autophagy.
Results: Mice with USP9Xinhibition exhibited impaired cognitive and memory functions. An increase in the APP levels and Tau hyperphosphorylation in the DG resembled AD-like pathology. Neurons exhibited abnormal functions, altered dendritic spine morphology, increase in neuronal apoptosis, and dysfunctions, similar to neuron loss observed in AD.
Conclusion: Investigating the role of USP9X in AD could provide valuable insights for developing novel diagnostic and therapeutic strategies for AD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207322 | PMC |
| http://dx.doi.org/10.1111/cns.70493 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Functional Connectivity of Hippocampal Circuits and Visual Memory Function in Children and Adolescents With Perinatal Stroke.
Hum Brain Mapp
September 2025
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Perinatal stroke is a vascular injury occurring early in life, often resulting in motor deficits (hemiplegic cerebral palsy/HCP). Comorbidities may also include poor neuropsychological outcomes, such as deficits in memory. Previous studies have used resting state functional MRI (fMRI) to demonstrate that functional connectivity (FC) within hippocampal circuits is associated with memory function in typically developing controls (TDC) and in adults after stroke, but this is unexplored in perinatal stroke.
View Article and Find Full Text PDFPeripheral Inflammation Is Associated With Greater Neuronal Injury and Lower Episodic Memory Among Late Middle-Aged Adults.
J Neurochem
September 2025
Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Elucidating the earliest biological mechanisms underlying Alzheimer's disease (AD) is critical for advancing early detection strategies. While amyloid-β (Aβ) and tau pathologies have been central to preclinical AD research, the roles of peripheral biological processes in disease initiation remain underexplored. We investigated patterns of F-MK6240 tau positron emission tomography (PET) and peripheral inflammation across stages defined by Aβ burden and neuronal injury in n = 132 (64.
View Article and Find Full Text PDFDownregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway.
Behav Brain Res
September 2025
Department of neurology, Hebei Medical University Third Hospital, Hebei 050000,Shijiazhuang,China; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei 050000,Shijiazhuang,China. Electronic address:
Background: Mitochondrial dysfunction is considered to be an important pathogenesis of cognitive impairment in Alzheimer's disease(AD). Activation of Nrf2 can improve cognitive impairment in AD mice, but the underlying mechanism remains to be elucidated. This research aims to investigate the intrinsic molecular mechanism of Nrf2 in mitochondrial biogenesis related to cognitive impairment of AD mice.
View Article and Find Full Text PDFGestational inoculation by the Zika virus causes cognitive impairment and NaK-ATPase activity imbalance in frontal cortex of adult male and female Wistar rat's offspring.
Brain Res
September 2025
Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil; Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre,
It has been recently described the Congenital Zika Syndrome (CZS). Children from pregnant women who were infected by the virus have expressed a set of symptoms, particularly involving neurological disorders such as microcephaly. Animal models have been conducted aiming to enhance the knowledge about the CZS and giving support for future studies proposing prevention and treatment for this condition.
View Article and Find Full Text PDFYXQN Ameliorates Vascular Dementia in 2-VO Rats via Inhibition of Ferroptosis.
J Ethnopharmacol
September 2025
Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China; Academy of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China; The Key Discipline for Integration of Chinese and Western B
Ethnopharmacological Relevance: YangXue QingNao Wan (YXQN) is a compound Chinese medicine comprising of 11 traditional Chinese medicinal herbs, including Angelica sinensis, Ligusticum chuanxiong, and Paeonia lactiflora, etc. Previous studies in our laboratory have demonstrated that YXQN improved cerebral microcirculation in hypertensive rats. However, its efficacy and underlying mechanisms in treating vascular dementia (VaD) remain unclear.
View Article and Find Full Text PDF