Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Geographical variations in the frequency of oncogenic driver alterations in non-small cell lung cancer (NSCLC) are observed worldwide, likely influenced by genetic and environmental factors. Radon, a leading cause of lung cancer in nonsmokers, may influence NSCLC's molecular profile.
Objectives: This study aims to explore the potential correlation between estimated indoor radon concentrations and the frequency of driver alterations in NSCLC across Europe.
Design: Ecological study of European countries with available data on indoor radon exposure (estimated mean levels and the proportion (%) of dwellings with concentrations >200 and >400 Bq/m), and frequency of NSCLC actionable genomic alterations (, ) from PubMed articles and meeting abstracts with sample size >100 patients.
Methods: We retrospectively analyzed NSCLC molecular data and radon exposure levels from European countries. Radon data, including the mean and proportion (%) of dwellings with concentrations >200 and >400 Bq/m, were sourced from the European Commission Report 2005. NSCLC molecular alteration frequency (, ) was extracted from PubMed articles with sample sizes >100 patients. The correlation between molecular alteration frequencies and country-specific radon data were assessed.
Results: Data on radon exposure and / frequency were available for 21 European countries. Five countries had mean radon levels >100 Bq/m, and eight countries had ⩾3% of dwellings with concentrations >400 Bq/m. The median frequency of mutations and fusions was 11.3% (range 7%-18.1%) and 4.1% (range 3.4%-12%), respectively. A positive correlation was found between estimated -fusion frequency and the percentage of dwellings with >400 Bq/m ( = 0.72, = 0.001). No correlation was found between EGFR mutation frequency and radon exposure.
Conclusion: We found a positive correlation between estimated fusion frequency in NSCLC and the proportion of dwellings exceeding 400 Bq/m radon exposure in 21 European countries. Further research is needed to explore the potential influence of radon and other environmental factors on NSCLC with driver alterations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202949 | PMC |
| http://dx.doi.org/10.1177/17588359251351449 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Theoretical model for estimation and control of radon exposure dose considering ventilation pressure drop in ventilation networks.
J Environ Radioact
September 2025
School of Resources Environment and Safety Engineering, University of South China, Hengyang, Hunan, 421001, China.
To minimize the occupational radiation hazards for workers in uranium or associated radioactive underground mines, it is necessary to control the radon exposure dose in each branch of the mine ventilation network. Firstly, a mathematical model of determining potential alpha energy concentration (PAEC) of radon daughters in a single branch was proposed on the basis of the previous radon concentration calculation model in the ventilation network considering ventilation pressure drop. Then, two estimation models of radon exposure dose based on the equilibrium radon concentration and PAEC of radon daughters are introduced.
View Article and Find Full Text PDFEstimations of effective doses received from naturally occurring radioactivity in polymetallic nodules from the deep sea.
Sci Rep
September 2025
Federal Institute for Geosciences and Natural Resources (BGR), Stilleweg 2, 30655, Hannover, Germany.
The strategic importance of metals found in deep-sea polymetallic nodules has spurred a surge in interest for their exploitation. However, nodules are known to incorporate radionuclides during their growth, so that any industrial processing would involve classifying them as naturally occurring radioactive materials (NORM). As the start of deep-sea mining gets closer, concerns about elevated exposure to radiation that could result from the handling of nodules has recently been raised.
View Article and Find Full Text PDFAlpha emitter concentrations of natural radionuclides and radiological hazard assessment of soil samples in the Halabja governorate, Iraq.
Isotopes Environ Health Stud
August 2025
Department of Physics, College of Science, University of Raparin, Ranya, Iraq.
Naturally occurring radioactive gases in soil, such as radon, are recognized for their significant impact on local air quality and potential health risks to nearby populations. The disturbance of the Earth's surface through excavation activities can enhance the release of these gases, increasing the likelihood of radon exposure. This study investigates soil samples collected from various sites across the Halabja governorate in Iraq to provide a comprehensive evaluation of the area's radiological profile.
View Article and Find Full Text PDFRadon exhalation rate and emanation factor values in relation to different soil characteristics.
Appl Radiat Isot
August 2025
Department of Radiochemistry and Radioecology, University of Pannonia, Veszprém, Hungary. Electronic address:
The natural background radiation to humans comes both from outside the Earth (cosmic radiation) and from radioactive isotopes found on Earth (terrestrial radiation). Radionuclides of terrestrial origin are partly external exposure and partly internal exposure via ingestion and inhalation. One of the most important sources of external terrestrial radiation is soil, where the most significant isotopes found are uranium-238, uranium-235 and thorium-232, members of the decay series, and potassium-40.
View Article and Find Full Text PDFAnalysis of Ra content and Rn exhalation rates in soil samples from Wukro, Tigray, using SSNTDs.
F1000Res
August 2025
Department of Physics, CNCS, Mekelle University, Mek'ele, Tigray, Ethiopia.
Background: Radon gas, a decay product of radium, is a significant environmental health risk due to its radioactive properties. Understanding the radium content and radon exhalation rates in soil is crucial for evaluating potential radiological hazards and ensuring environmental safety.
Methods: Soil samples were collected from twelve different locations in Wukro, Tigray, representing various soil types.