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Anaplastic large cell lymphoma (ALCL) represents one of the rare types of non-Hodgkin lymphoma. We describe a case of primary bone anaplastic lymphoma kinase (ALK)-positive ALCL presented as a giant extraskeletal mass with extensive coagulation necrosis. There have been only a few case reports detailing radiological imaging of primary bone ALCL with extraskeletal extension and to the best of our knowledge this is the first documented case associating ALCL with coagulation necrosis.
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http://dx.doi.org/10.1016/j.radcr.2025.05.062 | DOI Listing |
J Pediatr Surg
September 2025
Division of Pediatric General and Thoracic Surgery, Seattle Children's Hospital, 4800 Sand Point Way NE, Ocean 9.A.220, Seattle, WA 98105, USA; Department of Surgery, University of Washington, 1959 Pacific Street, Box 356410, Seattle, WA 98195, USA.
Purpose: First rib fractures in children are typically associated with high-impact trauma; atraumatic etiologies remain understudied. The purpose of this study is to evaluate the presentation and management of pediatric first rib fractures in the absence of major trauma.
Methods: This is a retrospective study of pediatric patients diagnosed with first rib fractures between 2000-2023 at a quaternary, free-standing children's hospital.
Int J Biol Macromol
September 2025
Faculty of Applied Sciences, Macao Polytechnic University, Macao. Electronic address:
Osteosarcoma (OS), the most prevalent primary bone malignancy in adolescents, is characterized by aggressive progression and early metastasis. However, the epigenetic drivers of its metastatic heterogeneity remain poorly understood. Herein, we integrated bulk DNA methylation profiling and single-cell RNA sequencing (scRNA-seq) to elucidate the epigenetic mechanisms driving OS metastatic heterogeneity.
View Article and Find Full Text PDFCalcif Tissue Int
September 2025
Department of Endocrinology, Post-Graduate Institute of Medical Education and Research (PGIMER), 001, Nehru Extension Block, Chandigarh, India.
Rare diseases, defined by the 2002 Rare Disease Act, affect fewer than 5 in 10,000 individuals. Rare metabolic bone diseases (MBDs), such as osteogenesis imperfecta, hypophosphatasia, osteopetrosis, and other unclassified disorders, can disrupt bone development and remodeling, posing diagnostic and management challenges. This study analyzed data from the rarembd.
View Article and Find Full Text PDFJ Orthop Res
September 2025
Department of Mechanical Engineering, University of Louisville, Louisville, Kentucky, USA.
The use of cementless total knee arthroplasty (TKA) has significantly increased over the past decade. However, there is no objective criteria or consensus on parameters for patient selection for cementless TKA. The purpose of this study was to develop a machine learning model based on patient and radiographic parameters that could identify patients indicated for cementless TKA.
View Article and Find Full Text PDFOrthop Traumatol Surg Res
September 2025
CHU de Grenoble-Alpes, Université de Grenoble-Alpes, Laboratoire TIMC-IMAG, Unité de Chirurgie Orthopédique et Traumatologique, CNRS UMR 5525, Boulevard de la Chantourne, 38700 La Tronche, France.
Percutaneous pelvic screwing (PPS) enables fixation of traumatic or atraumatic fractures with little or no displacement, or displaced but reduced fractures, and preventive fixation of primary or secondary tumoral lesions. It is a relatively recent technique, and indications are evolving with progress in pre- and intra-operative imaging. Morbidity is lower than with open surgery.
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