Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.2174/092986733215250325111534DOI Listing

Publication Analysis

Top Keywords

link lipids
4
lipids inflammation
4
inflammation focus
4
focus targeting
4
targeting sialidase
4
sialidase activity
4
activity novel
4
novel strategy
4
strategy anti-atherosclerotic
4
anti-atherosclerotic therapy
4

Similar Publications

Background: Dyslipidemia and chronic liver disease (CLD) remain major global health challenges with high morbidity and mortality rates. Although extensively studied, the association between dyslipidemia and CLD remains incompletely elucidated. Depressive symptoms, an increasingly prevalent comorbidity, have been widely implicated in both conditions.

View Article and Find Full Text PDF

Metabolic interplay of SCFA's in the gut and oral microbiome: a link to health and disease.

Front Oral Health

August 2025

Conservative Dentistry and Endodontics, AB Shetty Memorial Institute of Dental Sciences, Nitte (deemed to be) University, Mangalore, India.

Short-chain fatty acids (SCFAs), primarily acetate (C2), propionate (C3), and butyrate (C4), are crucial microbial metabolites formed by the fermentation of dietary fibers by gut microbiota in the colon. These SCFAs, characterized by fewer than six carbon atoms, serve as an essential energy source for colonic epithelial cells and contribute approximately 10% of the body's total energy requirement. They are central to maintaining gut health through multiple mechanisms, including reinforcing intestinal barrier function, exerting anti-inflammatory effects, regulating glucose and lipid metabolism, and influencing host immune responses.

View Article and Find Full Text PDF

Background: This study aimed to investigate the gender-specific associations of skeletal muscle mass and fat mass with non-alcoholic fatty liver disease (NAFLD) and NAFLD-related liver fibrosis in two population-based studies.

Methods: Analyses were based on data from the MEGA (n = 238) and the MEIA study (n = 594) conducted between 2018 and 2023 in Augsburg, Germany. Bioelectrical impedance analysis was used to evaluate relative skeletal muscle mass (rSM) and SM index (SMI) as well as relative fat mass (rFM) and FM index (FMI); furthermore, the fat-to-muscle ratio was built.

View Article and Find Full Text PDF

Purpose: NOTCH3 is increasingly implicated for its oncogenic role in many malignancies, including meningiomas. While prior work has linked NOTCH3 expression to higher-grade meningiomas and treatment resistance, the metabolic phenotype of NOTCH3 activation remains unexplored in meningioma.

Methods: We performed single-cell RNA sequencing on NOTCH3 + human meningioma cell lines.

View Article and Find Full Text PDF

The association between asthma and chronic obstructive pulmonary disease overlap (ACO) and insulin resistance (IR) has not been adequately investigated. Triglyceride glucose (TyG) index-related obesity indices offer a novel measure for assessing IR. We aimed to explore the associations between these indices and ACO in US population.

View Article and Find Full Text PDF