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Auditory distractions can significantly impact driving safety by affecting a driver's ability to focus, react, and make decisions, and consequently increase Driver's Reaction Time. The present study aims to examine the impact of such distractions using experimental data employing the Vienna Test System (VTS). Eighty drivers (70% male, 30% female) from mixed traffic environments participated, resulting in 240 data samples across two age groups (young and mature). Reaction time was assessed under three conditions: (i) Normal, (ii) Music, and (iii) Call using the VTS, which includes visual and auditory stimuli requiring physical reactions, thus closely simulating real-life driving scenarios. Results showed that male drivers' reaction time increased by 4.8% and 20.1% under Music and Call conditions, respectively, while female drivers exhibited increases of 6.1% and 13.5%, respectively. The comparison of reaction time among young and mature groups under each condition indicated that Call distractions led to the highest increase (12.0%) in reaction time, followed by Normal (10.8%) and Music (8.3%). A second-degree polynomial equation was proposed to estimate reaction time from age. Additionally, the Weibull Accelerated Failure Time (AFT) model identified key factors affecting reaction time under normal conditions, resulting in a formulated mathematical expression. A validation experiment using real-world crash and near-crash videos reinforced the findings. The study provides empirical insights for enhancing safety measures and could be leveraged within advanced driver assistance systems (ADAS).
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http://dx.doi.org/10.1016/j.aap.2025.108154 | DOI Listing |
Chem Commun (Camb)
September 2025
Inorganic Chemistry I Institute, Ruhr-Universität Bochum, Universitätsstrasse 150, 44801 Bochum, Germany.
Herein, we report a solid-state polycyclotrimerization of 1,4-diethynylbenzene using mechanochemical activation in a ball mill, yielding a highly porous and hydrophobic hyperbranched polymer (HBP) with a specific surface area of up to 570 m g. The reaction, catalyzed by Fe(hmds) and conducted under solvent-free conditions, was optimized by varying milling time and frequency. This method enables the efficient synthesis of insoluble, porous organic polymers with high yields (up to 95%) and offers an environmentally friendly alternative to traditional solution-based polymerizations.
View Article and Find Full Text PDFJ Mass Spectrom
October 2025
Department of Chemistry and Technology of Drugs, "Sapienza" University of Rome, Rome, Italy.
Ionic liquids (ILs) are a class of organic salts with melting points below 100°C. Owing to their unique chemical and physical properties, they are used as solvents and catalysts in various chemical transformations, progressively replacing common volatile organic solvents (VOCs) in green synthetic applications. However, their intrinsic ionic nature can restrict the use of mass spectrometric techniques to monitor the time progress of a reaction occurring in an IL medium, thus preventing one from following the formation of the reaction products or intercepting the reaction intermediates.
View Article and Find Full Text PDFRSC Adv
September 2025
Department of Chemical Engineering and Green Technology, Institute of Chemical Technology (ICT) Mumbai Maharashtra 400019 India
The sustainable synthesis of bio-based monomers from renewable biomass intermediates is a central goal in green chemistry and biorefinery innovation. This study introduces a synergistic catalytic-enzymatic strategy for the efficient and eco-friendly oxidation of 5-hydroxymethylfurfural (5-HMF) into 2,5-furandicarboxylic acid (FDCA), a key monomer for next-generation biodegradable plastics. The catalytic phase employed non-noble metal catalysts, MnO and Co-Mn supported on activated carbon (Co-Mn/AC), under mild batch reaction conditions at 90 °C.
View Article and Find Full Text PDFBackground: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involvement of a significant portion of the body surface area. To date, no association between GBFDE and chlordiazepoxide has been reported in the literature.
View Article and Find Full Text PDFChem Sci
September 2025
Molecular AI, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca Gothenburg Sweden
Incorporating non-natural amino acids (NNAAs) into peptides enhances therapeutic properties, including binding affinity, metabolic stability, and half-life time. The pursuit of novel NNAAs for improved peptide designs faces the challenge of effective synthesis of these building blocks as well as the entire peptide itself. Solid-Phase Peptide Synthesis (SPPS) is an essential technology for the automated assembly of peptides with NNAAs, necessitating careful protection for effective coupling of amino acids in the peptide chain.
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