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Article Abstract
Background: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involvement of a significant portion of the body surface area. To date, no association between GBFDE and chlordiazepoxide has been reported in the literature.
Case Report: The authors present the case of a 40-year-old male inpatient in the psychiatry department of a tertiary care hospital in Assam, India. The patient was admitted in an alcohol withdrawal state and was initially prescribed chlordiazepoxide at a dose of 60 mg/day. He developed GBFDE within a day of chlordiazepoxide administration. The drug was discontinued, and he was treated with oral and topical corticosteroids instead, resulting in a significant improvement.
Conclusion: Chlordiazepoxide is a rare but potential trigger of GBFDE. Clinicians should closely monitor patients on chlordiazepoxide for possible signs of GBFDE.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416551 | PMC |
| http://dx.doi.org/10.17816/CP15563 | DOI Listing |
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