Multiplicity corrections in life sciences: challenges and consequences.

Int J Epidemiol

Department of Bioinformatics, Semmelweis University, H-1094 Budapest, Hungary.

Published: June 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205177PMC
http://dx.doi.org/10.1093/ije/dyaf098DOI Listing

Publication Analysis

Top Keywords

multiplicity corrections
4
corrections life
4
life sciences
4
sciences challenges
4
challenges consequences
4
multiplicity
1
life
1
sciences
1
challenges
1
consequences
1

Similar Publications

Genome-wide iterative fine-mapping for non-Gaussian phenotypes.

Sci Rep

August 2025

Department of Statistics, Virginia Tech, Blacksburg, VA, 24060, USA.

Fine-mapping seeks to identify causal variants associated to a phenotype of interest. Fine-mapping searches through genomic regions previously identified by single marker analysis of genome-wide association studies (GWAS) data. This two-stage approach (1) often fails to identify causal variants with smaller effect sizes, and (2) does not properly correct for multiple comparisons.

View Article and Find Full Text PDF

A phase-controlled direction-tunable surface plasmon polariton (SPP) coupler is designed based on a plasmonic phased array (PPA) served by equally spaced stripe waveguides. It can couple phased SPPs fed through the PPA into the integrated plasmonic slab waveguide as directional SPPs, and the output SPPs can be steered by tuning the excitation phases. Theoretical investigations about a 7-element-PPA-based SPP coupler based on the finite-difference time-domain method indicate that the output SPPs can be dynamically steered over a range of up to 59.

View Article and Find Full Text PDF

Correction: Mitochondrial genome assembly and comparative analysis of decaploid .

Front Plant Sci

July 2025

School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Sanya, China.

[This corrects the article DOI: 10.3389/fpls.2025.

View Article and Find Full Text PDF

State-of-the-art adaptive optics (AO) systems perform non-linear Fourier-type wavefront sensing for real-time corrections of dynamic wavefront aberrations. This general class of sensors uses a filtering mask in the focal plane that converts phase fluctuations of the incoming light into intensity variations in the subsequent pupil plane. Due to their high sensitivity, Fourier-type wavefront sensors (WFSs) are the sensors of choice for many current and upcoming AO systems in ophthalmic imaging, free-space optical communications (FSOC) and astronomical ground-based telescopes such as the forthcoming generation of extremely large telescopes (ELTs).

View Article and Find Full Text PDF