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Wrist photoplethysmogram (PPG) signals are widely used for physiological monitoring in consumer devices. However, the PPG is highly susceptible to noise, which can reduce the accuracy of monitored parameters. The aim of this study was to identify factors which influence PPG signal quality. Data from the Aurora-BP dataset were used, consisting of reflectance wrist PPG signals measured from 1,142 subjects of varying ages and health statuses. Measurements were acquired in supine, sitting, and standing postures, and with the sensor held at different heights. Three signal quality metrics were calculated: the signal-to-noise ratio (SNR), the perfusion index (PI), and the template-matching correlation coefficient (TMCC). When comparing between postures with the sensor held at a natural height, quality was greatest in the supine position (SNR: 18.6 dB), followed by sitting with the arm resting in the lap (13.7 dB), and lowest whilst standing with the arm hanging alongside (9.0 dB) (p < 0.001). Signal quality increased as the arm was raised to heart height: whilst sitting, quality was lowest with the arm alongside the body (10.5 dB), and increased when the sensor was held in the lap (13.7 dB) and at heart height (15.5 dB) (p < 0.001). Similar trends were observed for the TMCC and PI. Findings were mixed for the influence of participant characteristics on signal quality. The SNR and TMCC, but not the PI, increased with age. The SNR either decreased or remained constant at darker skin tones when controlling for PPG DC amplitude, compared to constant or increased when allowing DC amplitude to vary. In conclusion, this study identified the impacts of posture and sensor height on signal quality, with highest qualities observed in the supine posture and with the sensor at heart height. It also highlights the importance of adjusting LED light intensity to maintain signal quality across skin tones.
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http://dx.doi.org/10.1371/journal.pdig.0000585 | DOI Listing |
Curr Genet
September 2025
Fermentation and Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, 180001, India.
Trichoderma species exhibit remarkable versatility in adaptability and in occupying habitats with lifestyles ranging from mycoparasitism and saprotrophy to endophytism. In this study, we present the first high-quality whole-genome assembly and annotation of T. lixii using Illumina HiSeq technology to explore the mechanisms of endophytic lifestyle and plant colonization.
View Article and Find Full Text PDFJpn J Radiol
September 2025
Department of Radiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Background: Stroke, frequently associated with carotid artery disease, is evaluated using carotid computed tomography angiography (CTA). Dual-energy CTA (DE-CTA) enhances imaging quality but presents challenges in maintaining high image clarity with low-dose scans.
Objectives: To compare the image quality of 50 keV virtual monoenergetic images (VMI) generated using Deep Learning Image Reconstruction (DLIR) and Adaptive Statistical Iterative Reconstruction-V (ASIR-V) algorithms under a triple-low scanning protocol in carotid CTA.
Int J Cancer
September 2025
Medical Department, iOMEDICO, Freiburg, Germany.
Existing prognostic scores for metastatic colorectal cancer (mCRC) are based on randomized clinical trial data and focus on parameters evaluated at the start of first-line (1L) treatment. Unlike these, the modified mCRC prognostic score (mCCS) was developed using real-world data from the German tumor registry colorectal cancer (TKK) and is based on pre-1L treatment information. It predicts overall survival (OS) for patients with RAS-wild-type (WT) mCRC using five tumor characteristics identified as independent negative prognostic factors.
View Article and Find Full Text PDFAdv Healthc Mater
September 2025
Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, M5T 0S8, Canada.
Accurate brain signal recording and precise electrode placement are critical for the success of neuromodulation therapies such as deep brain stimulation (DBS). Addressing these challenges requires deep brain electrodes that provide high-quality, stable recordings while remaining compatible with high-resolution medical imaging modalities like magnetic resonance imaging (MRI). Moreover, such electrodes shall be cost-effective, easy to manufacture, and patient-compatible.
View Article and Find Full Text PDFPlant Biotechnol J
September 2025
National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan, China.
Abscisic acid (ABA) and calcium respectively work as crucial plant hormones and second signalling molecules in the regulation of fruit development and quality formation, including the sugar content and flavour quality. However, the regulatory mechanisms of fruit sugar accumulation arising from the interaction between ABA and calcium have not yet been fully elucidated. Here, we show that the application of ABA or calcium enhances sugar accumulation in sweet orange (Citrus sinensis) fruit, accompanied by upregulation of the expression level of tonoplast sugar transporter 2 (CsTST2), which mediates the transport of sugars into the vacuole.
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