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http://dx.doi.org/10.1038/s41375-025-02661-z | DOI Listing |
Leukemia
August 2025
Sprint Bioscience AB, Huddinge, Sweden.
PLoS One
April 2024
Departments of Biological Chemistry, Genentech, Inc., South San Francisco, California, United States of America.
PLoS One
April 2024
Department of Early Discovery Biochemistry, Genentech, South San Francisco, California, United States of America.
Disulfide constrained peptides (DCPs) show great potential as templates for drug discovery. They are characterized by conserved cysteine residues that form intramolecular disulfide bonds. Taking advantage of phage display technology, we designed and generated twenty-six DCP phage libraries with enriched molecular diversity to enable the discovery of ligands against disease-causing proteins of interest.
View Article and Find Full Text PDFJ Org Chem
June 2023
Centre of New Technologies, University of Warsaw; S. Banacha 2c, 02-097 Warsaw, Poland.
Chemical modifications of the mRNA cap structure can enhance the stability, translational properties, and half-life of mRNAs, thereby altering the therapeutic properties of synthetic mRNA. However, cap structure modification is challenging because of the instability of the 5'-5'-triphosphate bridge and N7-methylguanosine. The Suzuki-Miyaura cross-coupling reaction between boronic acid and halogen compound is a mild, convenient, and potentially applicable approach for modifying biomolecules.
View Article and Find Full Text PDFACS Chem Biol
April 2023
Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, United States.
Wnt ligands are critical for tissue homeostasis and form a complex with LRP6 and frizzled coreceptors to initiate Wnt/β-catenin signaling. Yet, how different Wnts achieve various levels of signaling activation through distinct domains on LRP6 remains elusive. Developing tool ligands that target individual LRP6 domains could help elucidate the mechanism of Wnt signaling regulation and uncover pharmacological approaches for pathway modulation.
View Article and Find Full Text PDF