Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310507PMC
http://dx.doi.org/10.1038/s41375-025-02661-zDOI Listing

Publication Analysis

Top Keywords

dcps synthetic
4
synthetic lethal
4
lethal therapeutic
4
therapeutic target
4
target acute
4
acute myeloid
4
myeloid leukemia
4
leukemia expressing
4
expressing low
4
low levels
4

Similar Publications

Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform.

PLoS One

April 2024

Departments of Biological Chemistry, Genentech, Inc., South San Francisco, California, United States of America.

Article Synopsis
  • * This study developed a platform using diverse DCP libraries to discover new peptide therapeutics, achieving a significant diversity of potential candidates.
  • * The research demonstrated success in creating strong inhibitors for specific proteins, highlighting the potential of this platform to improve the discovery process for peptide-based drugs.
View Article and Find Full Text PDF

A phage-displayed disulfide constrained peptide discovery platform yields novel human plasma protein binders.

PLoS One

April 2024

Department of Early Discovery Biochemistry, Genentech, South San Francisco, California, United States of America.

Disulfide constrained peptides (DCPs) show great potential as templates for drug discovery. They are characterized by conserved cysteine residues that form intramolecular disulfide bonds. Taking advantage of phage display technology, we designed and generated twenty-six DCP phage libraries with enriched molecular diversity to enable the discovery of ligands against disease-causing proteins of interest.

View Article and Find Full Text PDF

Chemical modifications of the mRNA cap structure can enhance the stability, translational properties, and half-life of mRNAs, thereby altering the therapeutic properties of synthetic mRNA. However, cap structure modification is challenging because of the instability of the 5'-5'-triphosphate bridge and N7-methylguanosine. The Suzuki-Miyaura cross-coupling reaction between boronic acid and halogen compound is a mild, convenient, and potentially applicable approach for modifying biomolecules.

View Article and Find Full Text PDF

Wnt ligands are critical for tissue homeostasis and form a complex with LRP6 and frizzled coreceptors to initiate Wnt/β-catenin signaling. Yet, how different Wnts achieve various levels of signaling activation through distinct domains on LRP6 remains elusive. Developing tool ligands that target individual LRP6 domains could help elucidate the mechanism of Wnt signaling regulation and uncover pharmacological approaches for pathway modulation.

View Article and Find Full Text PDF