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http://dx.doi.org/10.1016/j.ijrobp.2025.02.029 | DOI Listing |
JCEM Case Rep
October 2025
Henry Ford Providence Southfield Internal Medicine, Southfield, MI 48075, USA.
We report a 28-year-old woman with refractory hypoglycemia, hypotension, and profound fatigue found to have panhypopituitarism secondary to Sheehan syndrome. Although she had a remote history of postpartum hemorrhage marked by agalactia and secondary amenorrhea, her diagnosis was delayed until she developed an adrenal crisis in the setting of acute pyelonephritis. Comprehensive endocrine testing confirmed secondary adrenal insufficiency, central hypothyroidism, hypogonadotropic hypogonadism, and lactotroph failure; Magnetic resonance imaging demonstrated a partially empty sella consistent with remote pituitary infarction.
View Article and Find Full Text PDFJACC Adv
July 2025
Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Critical cardiac illness in the setting of pregnancy presents a unique and complex challenge requiring multidisciplinary expertise and coordination. Physiologic changes of pregnancy can unmask or exacerbate underlying cardiac disease, placing both patient and fetus at significant risk. This review provides a comprehensive approach to the management of critically ill pregnant individuals with cardiac disease within the cardiac intensive care unit.
View Article and Find Full Text PDFInt J Mol Sci
July 2025
Section of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine, University of Verona and Verona University and Hospital Trust (AOUI), 37134 Verona, Italy.
Mechanistic relationships between heat shock protein 90 (HSP90) and human epidermal growth factor receptor 2 (HER2) are complex and clinical correlations in breast cancer remain inconsistent. We investigated the role of HSP90 expression in the response of breast cancer cells to HER2-targeted treatments, by measuring cell viability/proliferation and protein expression after genetic and pharmacologic HER2/HSP90 modulation. HSP90 expression was also assessed by immunohistochemistry in a series of 72 metastatic, HER2+ breast cancer patients.
View Article and Find Full Text PDFCirculating blood proteins and enzymes are maintained within normal physiological and clinically relevant concentration ranges. Excursions from normality include diagnostic markers and causes of disease. Rapid and persistent changes in the levels and functions of circulating blood components can reflect the functions of multiple endocytic lectin receptors.
View Article and Find Full Text PDFPediatr Nephrol
July 2025
Department of Pediatric Nephrology, Faculty of Medicine, Çukurova University, Adana, Türkiye.
Background: This study aimed to assess fluid status in pediatric patients on peritoneal dialysis by combining ultrasonography and bioimpedance spectroscopy (BIS). It specifically focused on examining the changes in volume status following a 2-h dwell time ultrafiltration exchange and evaluating the reliability of these techniques.
Methods: Thirteen pediatric patients on peritoneal dialysis were enrolled in this study, and their hydration status was assessed clinically.