HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic Combinations.

Mechanistic relationships between heat shock protein 90 (HSP90) and human epidermal growth factor receptor 2 (HER2) are complex and clinical correlations in breast cancer remain inconsistent. We investigated the role of HSP90 expression in the response of breast cancer cells to HER2-targeted treatments, by measuring cell viability/proliferation and protein expression after genetic and pharmacologic HER2/HSP90 modulation. HSP90 expression was also assessed by immunohistochemistry in a series of 72 metastatic, HER2+ breast cancer patients.

Metastatic Melanoma Prognosis Prediction Using a TC Radiomic-Based Machine Learning Model: A Preliminary Study.

: The approach to the clinical management of metastatic melanoma patients is undergoing a significant transformation. The availability of a large amount of data from medical images has made Artificial Intelligence (AI) applications an innovative and cutting-edge solution that could revolutionize the surveillance and management of these patients. In this study, we develop and validate a machine-learning model based on radiomic data extracted from a computed tomography (CT) analysis of patients with metastatic melanoma (MM).

Biobanks as an Indispensable Tool in the "Era" of Precision Medicine: Key Role in the Management of Complex Diseases, Such as Melanoma.

In recent years, medicine has undergone profound changes, strongly entering a new phase defined as the "era of precision medicine". In this context, patient clinical management involves various scientific approaches that allow for a comprehensive pathology evaluation: from preventive processes (where applicable) to genetic and diagnostic studies. In this scenario, biobanks play an important role and, over the years, have gained increasing prestige, moving from small deposits to large collections of samples of various natures.

Cumulative Dose from Recurrent CT Scans: Exploring the DNA Damage Response in Human Non-Transformed Cells.

Recurrent computed tomography (CT) examination has become a common diagnostic procedure for several diseases and injuries. Though each singular CT scan exposes individuals at low doses of low linear energy transfer (LET) radiation, the cumulative dose received from recurrent CT scans poses an increasing concern for potential health risks. Here, we evaluated the biological effects of recurrent CT scans on the DNA damage response (DDR) in human fibroblasts and retinal pigment epithelial cells maintained in culture for five months and subjected to four CT scans, one every four weeks.

Survival Analysis up to 8 Years of 304 Anatomical-Contour Implant-Supported Zirconia Crowns Fabricated with a Fully Digital Cast-Free Workflow and Directly Screwed on External Hexagonal Implant Connections Without the Interposition of a Ti-Base: A Multicentric Retrospective Study.

Purpose: To evaluate the real-life clinical results of monolithic zirconia (Zr) screw-retained crowns without the interposition of a titanium base (Ti-base) on external hex implants fabricated from intraoral scans and a cast-free approach in private practice.

Materials And Methods: Single external hex implants were restored with monolithic Zr crowns without the interposition of a Ti-base. The crowns were directly screwed on the external hex implant connections with a cast-free, fully digital workflow.

A digital protocol for the fabrication of anatomic-contour implant zirconia crowns directly screwed on external hexagonal implant connections without the interposition of a Ti-base component.

A straightforward and effective restorative option is proposed for implant-supported fixed prostheses with external connections by using monolithic zirconia without the interposition of a Ti-base component. The technique is based on a modification of the Brånemark connection used to link metal-ceramic or metal-composite resin restorations directly to the implant.

A modified scan technique for multiple abutment teeth using the trim and lock function.

Objectives: To describe a new protocol for digital scanning of multiple abutment teeth using the trim and lock software tools.

Methods: A reverse workflow technique was used. Scanning was performed with the interim restoration in position.

Survival analysis up to 7 years of 621 zirconia monolithic single crowns with feather-edge margins fabricated with a cast-free workflow starting from intraoral scans: A multicentric retrospective study.

Statement Of Problem: Clinical studies on the fabrication of monolithic zirconia restorations with a feather-edge tooth preparation from digital scans and a cast-free fully digital workflow are lacking.

Purpose: The purpose of this retrospective multicentric study in private practices was to evaluate the outcomes of monolithic zirconia crowns fabricated with feather-edge margins and a cast-free approach.

Material And Methods: A total of 621 teeth were prepared with feather-edge margins and restored with monolithic zirconia crowns fabricated with a fully digital cast-free workflow.

A diagnostically and digitally driven tooth preparation protocol by using a patient monitoring tool with an intraoral scanner.

Finding the right balance between the preservation of tooth structure and providing adequate space for the restorative material is a major challenge in prosthetic dentistry. A technique is presented using the patient monitoring tool available in standard software programs of an intraoral scanner to constantly monitor preparation dimensions in relation to the optimal definitive restoration.

Retrospective survival analysis of 110 lithium disilicate crowns with feather-edge marginal preparation.

Purpose: To evaluate the clinical performance of lithium disilicate (LiDiSi) crowns with a feather-edge finish line margin over a 9-year period.

Materials And Methods: In total, 110 lithium disilicate crowns, 40 anterior (36.3%) and 70 posterior (63.

Retrospective survival analysis of 261 lithium disilicate crowns in a private general practice.

Objectives: This retrospective study evaluated the clinical performance and long-term survival of glass-ceramic lithium disilicate all-ceramic restorations in anterior and posterior areas over a 10-year period.

Method And Materials: Following a consistent protocol over 10 years, 261 lithium disilicate crowns (IPS Empress 2, Ivoclar Vivadent), including 101 anterior (38.7%) and 160 posterior (61.