Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Relapsing polychondritis is a systemic disease characterized by inflammation of cartilage and proteoglycan-rich tissues leading to progressive deformity and dysfunction of the involved structures. Ear and nasal chondritis and/or polyarthritis are the most common clinical forms of the disease (80%), but all types of cartilage can potentially be involved. Due to the polymorphic nature of the disease, the diagnosis of relapsing polychondritis often remains unclear due to non-specific symptoms. In this article, we offer a clinical observation of this disease.

Download full-text PDF

Source
http://dx.doi.org/10.26442/00403660.2025.05.203212DOI Listing

Publication Analysis

Top Keywords

relapsing polychondritis
12
[treatment patient
4
patient relapsing
4
polychondritis case
4
case report]
4
report] relapsing
4
polychondritis systemic
4
disease
4
systemic disease
4
disease characterized
4

Similar Publications

Rationale: Tracheomalacia, typically seen in relapsing polychondritis,[1] is rarely reported in association with congenital heart disease (CHD). In patients with pulmonary hypoperfusion-type CHD, surgical repair results in a rapid increase in pulmonary blood flow, predisposing them to mucus retention, airway obstruction, and respiratory distress. We describe acute airway collapse in a patient with double outlet right ventricle and congenital bronchial stenosis following cardiac repair.

View Article and Find Full Text PDF

A Case of Relapsing Polychondritis with Multisystemic Involvement.

Clin Cosmet Investig Dermatol

August 2025

Department of Imaging, The Fifth People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.

Relapsing polychondritis is a rare immunologic disorder that can involve all cartilage and proteoglycan-rich tissues. Clinical symptoms of relapsing polychondritis are often associated with recurrent inflammatory manifestations and functional impairment of such tissues. The disease has an insidious onset, and the first symptoms and clinical manifestations vary, making it easy to misdiagnose and miss the diagnosis.

View Article and Find Full Text PDF

Background: Up to 22% of cancer patients treated with immune checkpoint inhibitors (ICIs) can experience immune-related adverse events (irAEs) that mimic rheumatic disease, such as relapsing polychondritis (RP), which is a rare autoimmune disease that mainly manifests as inflammation of airway cartilage.

Methods: We report a case of RP induced by humanized recombinant anti-PD-1 monoclonal antibody therapy (tislelizumab). 18F-Fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) contributed to the diagnosis of RP, and methylprednisolone was used to effectively control its progression.

View Article and Find Full Text PDF

VEXAS syndrome (Vacuoles, E1-enzyme, X-linked, Autoinflammation, and Somatic) is a recently identified late-onset autoinflammatory disorder characterized by a unique interplay between hematological and inflammatory manifestations. It results from somatic mutations in the gene, located on the short arm of the X chromosome. Initially, females were considered mere carriers, with the syndrome primarily affecting males over 50.

View Article and Find Full Text PDF

Rationale: Relapsing polychondritis is a rare autoimmune disease that commonly leads to tracheobronchial stenosis, presenting significant treatment challenges.

Patient Concerns: This case report describes a 64-year-old male with relapsing polychondritis who developed severe tracheobronchial stenosis.

Diagnoses: Computed tomography scanning revealed stenosis of the trachea and bronchi, while bronchoscopy confirmed occlusion or stenosis.

View Article and Find Full Text PDF