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Article Abstract
Background: The human body can spontaneously repair damaged bone tissue and cells; however, external interventions are required to support bone regeneration when the defect exceeds a critical threshold. Bone repair primarily involves the regeneration of both bone and cartilage defects. Natural polyphenols, characterized by polyphenolic hydroxyl structures, readily integrate with other biomaterials to modulate endogenous microenvironment regulation and enhance bone defect repair.
Aim Of Review: In this review, we first examine the various sources of natural polyphenols and subsequently discuss their applications in bone and cartilage repair. We then summarize the iterative updates that have evolved through technological innovations, including bone grafting, tissue engineering, and organoids, as well as preclinical and clinical examples of osteogenic systemic therapies. In addition, it highlights the potential of integrating polyphenols into current regenerative medicine technologies.
Key Scientific Concepts Of Review: The development of polyphenol-based osteogenic systems has progressed into a new phase, characterized by highly integrated and multicomponent functionality. These systems offer simple and effective strategies for solving various bone defect conditions. However, standardized procedures are still needed to successfully translate polyphenol osteogenic systems into the clinic.
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