Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Plant-derived natural products have emerged as indispensable resources in modern drug discovery, and demonstrated remarkable potential across diverse disease domains. As a representative bioactive carotenoid, crocetin features a unique polyunsaturated oleic acid structure, extracted from the stigma of Crocus sativus L. Recent studies have revealed that crocetin has multiple pharmacological effects and biological activities, including anti-tumor, hepatoprotective, analgesic, neuroprotective, cardioprotective, anti-radiation and other protective effects. The present comprehensive review synthesizes cutting-edge advances in crocetin research, systematically evaluating its multifaceted pharmacological actions, pharmacokinetic profiles and dose-dependent toxicity thresholds. Particularly noteworthy is our mechanistic elucidation of crocetin's disease-modulating capabilities, which offers promising research prospects for the development and utilization of the medicinal value of crocetin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.intimp.2025.115125 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Production and functional characteristics of a novel hirudin variant with better anticoagulant activities than bivalirudin.
J Enzyme Inhib Med Chem
December 2025
School of Life Sciences, Jinggangshan University, Ji'an, China.
Current antithrombotic therapies face dual constraints of bleeding complications and monitoring requirements. Although natural hirudin provides targeted thrombin inhibition, its clinical adoption is hindered by sourcing limitations. This study developed a recombinant hirudin variant HMg (rHMg) with enhanced anticoagulant activity through genetic engineering and established cost-effective large-scale production methods.
View Article and Find Full Text PDFInitiation of tocilizumab within 24 hours in acute necrotizing encephalopathy is related to a good outcome: a systematic review.
J Neurol
September 2025
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Objective: To evaluate the clinical efficacy of tocilizumab, a interleukin-6 (IL-6) receptor blocker, for the treatment of acute necrotizing encephalopathy (ANE).
Methods: PubMed, Cochrane Library, Embase, and Web of Science were searched for systematic review based on PRISMA guidelines. ANE patients treated with and without tocilizumab were included.
As aging affects the appearance of the skin, anti-aging research has intensified in dermatology, skincare, and aesthetic medicine. Because natural aging takes a very long time, one essential anti-aging approach is to pharmacologically mimic aging, such as with D-galactose treatment. Hairless mice (HR-1) have been extensively used in skin research because of their lack of body hair and ease of animal care.
View Article and Find Full Text PDFSoy isoflavone yeast fermented extract inhibits contraction of rat ileal smooth muscle via opening of K channels and activation of intracellular cyclic adenosine monophosphate- and cyclic guanosine monophosphate-related pathways.
J Vet Med Sci
September 2025
Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Nippon Veterinary and Life Science University.
This study investigated the effects of soy isoflavone yeast fermented extract (soyF) and soy isoflavone yeast unfermented extract (soyN) on rat ileal smooth muscle contraction. SoyF and soyN inhibited carbachol (CCh)- or KCl-induced contraction in a concentration-dependent manner; however, these effects were stronger for CCh-induced contraction than that for KCl, and the relaxation effect was stronger for soyF than for soyN. SoyF-induced relaxation was attenuated by 4-aminopyridine (4-AP), a Kv channel inhibitor, and iberiotoxin (IbTX), a calcium-activated potassium channel (BK channel) inhibitor.
View Article and Find Full Text PDFSynergistic inhibition of autophagic flux and induction of apoptosis in cervical cancer cells by Mito-TEMPO and hyperthermia.
Environ Health Prev Med
September 2025
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, University of Toyama.
Background: Hyperthermia (HT), while a cancer treatment approach, isn't always effective alone. Therefore, identifying hyperthermia enhancers is crucial. We demonstrated that Mito-TEMPO ([2-[(1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) amino]-2-oxoethyl]-triphenylphosphanium, MT) acts as a potent thermosensitizer, promoting cell death in human cervical cancer (HeLa) cells.
View Article and Find Full Text PDF