Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Diabetes mellitus is a prevalent chronic disease that significantly impacts patients' quality of life and leads to serious complications, making effective blood glucose management essential. Current methods primarily include invasive fingertip blood testing and minimally invasive continuous glucose monitoring; however, the former presents psychological and infection risks, while the latter is costly and complex. Here, we report a phase separation-based porous microneedle-based analysis system, featuring a sampling module and a detection module, for point-of-care dermal interstitial fluid (DISF) glucose testing in a non-invasive, cost-effective and user-friendly manner. The accuracy and reliability of the proposed system have been thoroughly assessed through in vitro and on-body tests. Specifically, on-body trials with nine subjects during an oral glucose tolerance test (OGTT) confirmed consistent fluctuations between DISF and blood glucose concentrations, while routine tests among five volunteers (three healthy individuals and two patients with prediabetes) showed excellent capability of the proposed system for blood glucose prediction in a user-friendly and non-invasive manner. We believe this approach offers a promising, user-friendly solution for home-based, non-invasive, and rapid blood glucose management.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bios.2025.117701 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Western diet on body composition, locomotor performance and blood biochemical profile in the bank vole.
J Exp Biol
September 2025
Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Kraków, Poland.
The adverse effects of Western diets (WD), high in both fat and simple sugars, which contribute to obesity and related disorders, have been extensively studied in laboratory rodents, but not in non-laboratory animals, which limits the scope of conclusions. Unlike laboratory mice or rats, non-laboratory rodents that reduce body mass for winter do not become obese when fed a high-fat diet. However, it is not known whether these rodents are also resistant to the adverse effects of WD.
View Article and Find Full Text PDFDapagliflozin Reverses LPS-Induced Depressive-Like Behavior in Mice via Modulation of Glutamate and NF-κB.
Genes Brain Behav
October 2025
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Major depressive disorder is a prevalent and debilitating psychiatric illness that produces significant disability. Clinical data suggest that the pathophysiology of depression is due, in part, to a dysregulation of inflammation and glutamate levels in the brain. The systemic administration of lipopolysaccharide (LPS) has been shown to induce depressive-like behaviors in mice.
View Article and Find Full Text PDF[Biomarkers for an early detection of patients at risk of renal or cardiovascular disease].
Rev Med Liege
September 2025
Service de Chimie clinique, CHU Liège, Belgique.
Chronic kidney disease (CKD), heart failure (HF) and atherosclerotic cardiovascular disease (ASCVD) are pathologies that may remain silent for a long time and thus are largely underdiagnosed in clinical practice. The use of biomarkers may help detect people already suffering from these diseases at an early stage or at increased risk to develop them in a near future. The aim of this article is to discuss the place of the assays of albuminuria, natriuretic peptide (BNP/proBNP) and high-sensitivity troponin as well as lipoprotein(a) to help in the diagnosis and prognosis assessment of individuals at risk of presenting or developing a CKD, HF or ASCVD.
View Article and Find Full Text PDF[Plea for an early diagnosis of people at risk of developing symptomatic type 1 diabetes].
Rev Med Liege
September 2025
Service de Diabétologie, Nutrition et Maladies métaboliques, CHU Liège, Belgique.
Type 1 diabetes (T1D) is an autoimmune chronic disease that leads to the destruction of pancreatic beta cells and thus requires lifelong insulin therapy. Constraints and adverse events associated to insulin therapy are well known as well as the risk of long-term complications linked to chronic hyperglycaemia. Symptomatic T1D is preceded by a preclinical asymptomatic period, which is characterized by the presence of at least two auto-antibodies against beta cell without disturbances of blood glucose control (stage 1) or, in addition to immunological biomarkers, by the presence of mild dysglycaemia reflecting a defect of early insulin secretion (stage 2).
View Article and Find Full Text PDFMultiple Demographic, Lifestyle, and Biological Factors Associated With Brain Iron Deposition in the Basal Ganglia: A Comprehensive Analysis of 25,980 UK Biobank Participants.
Brain Behav
September 2025
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Radiology, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, Shandong Province, China.
Background: The susceptibility values of the basal ganglia reflect the health status of these nuclei. We aimed to explore the associations between various demographic characteristics, lifestyle factors, and biological factors that have the potential to contribute to magnetic susceptibility and investigate the comprehensive impact of these multiple factors on basal ganglia susceptibility values.
Methods: We included 25,980 participants from the UK Biobank.