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http://dx.doi.org/10.1093/eurjpc/zwaf345 | DOI Listing |
J Diabetes Complications
August 2025
Medical Laboratory Department, The First People's Hospital of Honghe State, Honghe State, Yunnan Province 661100, China. Electronic address:
Ecotoxicol Environ Saf
September 2025
Department of Cardiovascular Medicine, North China Petroleum Bureau General Hospital, Renqiu, Hebei 062550, China; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. Electronic address:
Background: Carotid atherosclerosis (CAS) is a major contributor to cerebrovascular incidence and mortality, yet its etiology in non-dyslipidemic individuals remains poorly understood. Emerging evidence suggests that environmental metal exposure may play a critical role in CAS development.
Methods: We conducted a retrospective matched case-control study involving 1290 non-dyslipidemic middle-aged and elderly individuals to examine the association between urinary metal exposure and CAS.
Clin Chem
September 2025
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Background: Direct measurement of low-density lipoprotein cholesterol (LDL-C) is widely used and recommended by professional society guidelines despite its potential limitations in patients with hypertriglyceridemia and low LDL-C. This study evaluated the performance of 3 direct LDL-C (LDL-CD) assays, 2 modern LDL-C calculation methods [LDL-C Martin (LDL-CM), LDL-C modified Sampson (LDL-CS)] and the conventional Friedewald (LDL-CF) method against the reference method, beta-quantification (LDL-CBQ).
Methods: A total of 181 remnant sera from patients with standard lipid panel orders or from patients with LDL-CBQ orders with triglycerides (TG) ≥ 400 mg/dL (4.
Nutr Metab Cardiovasc Dis
June 2025
IRCCS MultiMedica, Sesto San Giovanni (Milan), Italy; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy. Electronic address:
Aims: Hypertriglyceridaemia is a common clinical condition. Triglycerides (TGs) have long been recognised as a risk factor for atherosclerotic cardiovascular disease (ASCVD). Genetics, epidemiological studies and clinical trials have demonstrated a causal relationship between plasma triglycerides and ASCVD.
View Article and Find Full Text PDFBMC Med
August 2025
State Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.
Background: Remnant cholesterol (RC) has been implicated in cardiovascular diseases (CVDs) in populations of European ancestry, yet its causal role remains underexplored in populations of East Asian ancestry, which are underrepresented in genetic studies. We sought to investigate the causal association between circulating RC levels and CVD risk in East Asian populations.
Methods: We first conducted observational analyses of RC and multiple CVD outcomes in Chinese populations.