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The main objective of this study is to investigate whether different medical attitudes relate to COVID-19 vaccination uptake and approval of vaccine mandates. The theory of planned behavior and the health belief model suggest that individual attitudes towards medical approaches are important for vaccination uptake. We use data from a German online cross-sectional study comprising 4065 respondents conducted between September and October in 2022 on the use and acceptance of five pre-defined medical approaches: conventional medicine, Traditional European Medicine (Naturheilkunde), complementary medicine, integrative medicine, and alternative medicine. The two main outcome measures are: (1) COVID-19 vaccination uptake, differentiating between (a) rejected, (b) socially pressured and (c) endorsed vaccination; (2) attitudes towards mandatory COVID-19 vaccination, i.e., whether or not individuals endorse vaccination mandates. We employ logistic and multinomial logistic regressions to calculate average marginal effects (AME) and to account for the influence of different medical attitudes and for confounding variables. While vaccination uptake in general is high (91.0 % in the analytical sample), our multivariate results reveal that individuals with a positive disposition towards Traditional European Medicine (AME = 0.05; p < 0.01) and alternative medicine (AME = 0.02; p < 0.10) were, comparatively, more likely to reject COVID-19 vaccination. A positive disposition towards conventional medicine is associated with higher vaccination uptake (AME = 0.17; p < 0.001). Positive attitudes towards alternative medicine correlate with increased levels of feeling socially pressured into accepting the vaccination (AME = 0.05; p < 0.01). Approval levels for universal mandatory vaccination are low (43.9 %). Positive attitudes towards alternative (AME = -0.03; p < 0.1) and Traditional European Medicine (AME = -0.04; p < 0.05) negatively correlate with approval of vaccination mandates, while positive attitudes towards conventional medicine (AME = 0.05; p < 0.01) increase approval. Our findings suggest that different medical attitudes are simultaneously associated with vaccination uptake and mandate approval. This provides important knowledge for policy makers when designing vaccination schemes and for health professionals when consulting their heterogeneous group of patients.
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http://dx.doi.org/10.1016/j.vaccine.2025.127403 | DOI Listing |
Mol Biol Rep
September 2025
School of Arts and Sciences, Department of Natural and Applied Sciences, The American University of Iraq-Baghdad, Baghdad, Iraq.
The COVID-19 pandemic, caused by the continuously evolving SARS-CoV-2 virus, has presented persistent global health challenges. As novel variants emerge, many with enhanced transmissibility and immune evasion capabilities, concerns have intensified regarding the efficacy of existing vaccines and therapeutics. This review provides a comprehensive overview of the current landscape of COVID-19 vaccination, including the development and performance of monovalent and bivalent boosters, and examines their effectiveness against newly emerging variants of interest (VOIs) and variants under monitoring (VUMs), such as JN.
View Article and Find Full Text PDFDev World Bioeth
September 2025
Faculty of Law, University of Alberta, Edmonton, Alberta, Canada.
This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create 'valleys of death' that prevent innovation from reaching patients. Through the case of Glybera and other examples, it outlines a rehabilitative approach focused on reforming current systems through improved reimbursement schemes, regulatory streamlining, and more efficient manufacturing.
View Article and Find Full Text PDFPediatr Infect Dis J
September 2025
Hospital Universitario "Dr. José Eleuterio González," Monterrey, México.
We analyzed 59 pediatric pertussis cases during Mexico's 2024-2025 outbreak. Mortality was 13.6%, with low maternal Tdap coverage (27.
View Article and Find Full Text PDFInfect Control Hosp Epidemiol
September 2025
Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Background: Admission to shared hospital rooms are a risk factor of healthcare-associated (HA) SARS-CoV-2. Quantifying the impact of engineering controls such as ventilation and filtration is essential to informing resource utilization and infection prevention guidelines.
Methods: Multicenter test-negative study of patients exposed to SARS-CoV-2 in shared rooms across five hospitals between January and October, 2022.
Psychol Health
September 2025
Institute of Applied Health Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK.
Objective: There is a lack of research on how illness representations as represented in the Common Sense Self-Regulation Model (CS-SRM) emerge and develop. We aimed to describe the evolution of COVID-19 illness representations over time, and to explore associations with sociodemographic characteristics and protective behaviours.
Methods And Measures: This study (June 2020 release from lockdown to February 2021 after vaccine roll-out) used 17 independently recruited cross-sectional cohorts.