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A new member affiliated with the genus , designated as strain TCA, was isolated from a dechlorinating enrichment culture originating from a freshwater river sediment. Its genome includes a 3.5 Mb chromosome with a G + C content of 66.2% and a 3.2 kb plasmid with a G + C content of 59.9%.
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http://dx.doi.org/10.1128/mra.00202-25 | DOI Listing |
Front Microbiol
August 2025
Department of Medical Laboratory Diagnostics, School of Medical Technology, Shaoyang University, Shaoyang, China.
is an environmental opportunistic fungal pathogen, which can lead to invasive aspergillosis in immunocompromised individuals, and resistant to conventional antifungual agents has become a growing concern. This study investigated the antifungal activity and the molecular antifungal mechanisms of Cinnamaldehyde (CA) against , specifically its impact on metabolic pathways and protein metabolism. In susceptibility tests, CA was found to exhibit promising antifungal activity against in both solid and liquid culture (biomass) systems, with the minimum inhibitory concentration (MIC) determined as 40-80 μg/mL.
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August 2025
Hebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science & Technology, Qinhuangdao, China.
Background: has the ability to adapt to variable environments by modulating metabolism. The Tricarboxylic Acid Cycle (TCA), as a core metabolic process, is critical for the environmental adaptation and infection process of . Fumarate reductase FrdA is an important enzyme in the TCA cycle, mainly catalyzing the conversion of fumarate to succinate.
View Article and Find Full Text PDFFungal Biol
October 2025
Colin Ratledge Center for Microbial Lipids, School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, 255000, Shandong, China; School of Basic Medicine, Qilu Medical University, Zibo, 255300, Shandong, China. Electronic address:
Oleaginous filamentous fungus Mucor circinelloides harbors a GATA transcription activator AreA, which regulates nitrogen metabolism. In our previous study, deletion of AreA resulted in increased lipid production, while its overexpression reduced lipid synthesis. Although it is not a direct lipogenesis regulator, AreA influences metabolic flux by modulating nitrogen utilization pathways, which in turn affects carbon distribution.
View Article and Find Full Text PDFJ Hazard Mater
August 2025
Institute of Biotechnology, National Taiwan University, R412, No. 81, Chang-Xing St, Taipei 106, Taiwan; Agricultural Biotechnology Research Center, Academia Sinica, No.128, Section 2, Academia Rd., Nankang, Taipei 115, Taiwan; Department of Agricultural Chemistry, National Taiwan University No.1, S
Poly (butylene adipate-co-terephthalate) (PBAT) is a biodegradable polyester widely used in agriculture and packaging. However, its slow decomposition under natural conditions raises environmental concerns. In this study, we explored strategies to enhance PBAT degradation by Purpureocillium lilacinum strain BA1S.
View Article and Find Full Text PDFSynth Syst Biotechnol
December 2025
School of Light Industry and Food Engineering, Guangxi University, 100 Daxue East Road, Nanning, Guangxi, 530004, China.
l-Homoserine is a valuable intermediate with broad applications in the food, pharmaceutical, and chemical industries. Although has been engineered for the efficient biosynthesis of l-homoserine, both production efficiency and glucose conversion remain suboptimal. In this study, an engineered strain capable of high-yield l-homoserine production from glucose was successfully developed.
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