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Background: This study aimed to compare the efficacy of the Conformable TAG Thoracic Endoprosthesis (CTAG) and the Valiant Captivia System Stent Graft in thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD).
Methods: TBAD patients treated from 2016 to 2022 at a Chinese tertiary center with a CTAG or Captivia stent graft were eligible for inclusion, and their data were retrospectively collected and analyzed. Intraoperative characteristics, short-term outcomes during hospitalization, mid-term outcomes during follow-up, and aortic remodeling were analyzed and compared between 2 groups.
Results: In total, the study included 617 patients (372 CTAG and 245 Captivia). The baseline characteristics of both groups were comparable. Procedural details showed that the CTAG group had larger stent diameter (P < 0.001) and higher oversize ratio (P < 0.001) than the Captivia group and led to less intraoperative type I endoleak cases (P = 0.01). Complications during hospitalization, especially stroke, occurred more commonly in the Captivia group (P = 0.033). Mid-term outcomes, including readmission rate and aortic-related mortality, were comparable between the 2 groups. And CTAG performed better in aortic remodeling with higher expansion rate of true lumen than Captivia in the stented segment of aorta (P < 0.001).
Conclusion: Both CTAG and Captivia offered comparable and favorable mid-term survival rates and freedom from readmission in patients with TBAD. CTAG performed better during TEVAR operations and in short-term outcomes, including reducing intraoperative type I endoleak and avoiding complications during hospitalization. In addition, CTAG achieved an improved aortic remodeling effect in expanding the true lumen of aorta.
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http://dx.doi.org/10.1016/j.avsg.2025.06.002 | DOI Listing |
Cell Rep Med
September 2025
Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan 250012, China; Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong U
Abdominal aortic aneurysm (AAA) is a life-threatening condition lacking effective treatment. We investigate the role of the deubiquitinating enzyme USP21 in AAA development. Proteomic analysis reveals significant upregulation of USP21 in murine and human abdominal aortic tissues.
View Article and Find Full Text PDFHigh Blood Press Cardiovasc Prev
September 2025
Center for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich and University of Zürich, Wagistrasse 12, 8952, Schlieren, Switzerland.
Introduction: Epigenetic changes are important modulators of gene expression. The histone acetyltransferase gene non-derepressible 5 (Gcn5) is emerging as a pivotal epigenetic player in metabolism and cancer, yet its role in obesity and cardiovascular disease remains elusive.
Aims: To investigate Gcn5 role in obesity-related endothelial dysfunction.
J Cardiovasc Pharmacol
September 2025
Graduate School of Cardiology, Bengbu Medical University, Bengbu 233000, Anhui, China.
Chronic stress-induced cardiac hypertrophy remains a critical precursor to heart failure, with current therapies limited by incomplete mechanistic targeting. Cyclin-dependent kinases (CDKs), pivotal regulators of cell cycle and stress signaling, are emerging therapeutic targets in cardiovascular pathologies. Using bioinformatics analysis of human hypertrophic cardiomyopathy datasets (GSE5500, GSE136308) and a murine transverse aortic constriction (TAC) model, we investigated the therapeutic effects of the CDK inhibitor R547 (10 mg/kg, intraperitoneal every 3 days) on pressure overload-induced cardiac remodeling.
View Article and Find Full Text PDFJ Cardiovasc Pharmacol
September 2025
Department of Cardiovascular Medicine, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430060, China.
Nuclear factor erythrocyte 2-associated factor 2 (Nrf2) is an important transcriptional regulator that plays a protective role in myocardial remodeling. Omaveloxolone (Omav) acts as an activator of Nrf2 and plays a protective role by decreasing oxidative stress and inflammation. The purpose of this study was to explore the role of Omav in myocardial remodeling and investigate the potential mechanism involved.
View Article and Find Full Text PDFJTCVS Open
August 2025
State Key Laboratory of Cardiovascular Disease, Center of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Objective: To evaluate the remodeling of the distal aorta and outcomes after aortic surgery for type A aortic dissection (TAAD) in patients with Marfan syndrome and investigate whether morphologic characteristics of the dissection can predict negative remodeling.
Methods: Between 2013 and 2021, we performed total arch with a frozen elephant trunk for 325 patients with Marfan syndrome with DeBakey type I aortic dissection. Mean age was 47.