Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The significance of the photoreduction channel via the tryptophan triad in the cryptochrome (CRY) has been generally recognized. However, there is literature reporting the retention of biological function in the primary electron transfer (ET) pathway-impaired mutants in some CRY species. In this work, a secondary ET pathway is identified in the animal-like cryptochrome (aCRY) in the opposite direction of the primary ET pathway, involving ultrafast electron tunneling and proton transfer. Through sequence alignment, it is found that the proximal Trp (W) from the secondary ET pathway is conserved across all CRY species, which could be absent in the ancestral protein photolyases. This alternative ET pathway presumably triggers photoinduced conformational changes when the primary pathway is shut down upon random missense mutation, contributing to functional robustness.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jpclett.5c01003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structure-Bias Relationship of μ-Opioid Receptor Agonists.
Handb Exp Pharmacol
September 2025
Tsinghua University, Beijing, China.
The μ-opioid receptor (μOR) is the primary drug target of opioid analgesics such as morphine and fentanyl. Activation of μORs in the central nervous system inhibits ascending pain signaling to the cortex, thereby producing analgesic effects. However, the clinical use of opioid analgesics is severely limited by adverse side effects, including respiratory depression, constipation, addiction, and the development of tolerance.
View Article and Find Full Text PDFUnravelling novel microbial players in the breast tissue of TNBC patients: a meta-analytic perspective.
NPJ Biofilms Microbiomes
September 2025
Bioinformatics Group, Centre for Informatics Science (CIS), School of Information Technology and Computer Science (ITCS), Nile University, Giza, Egypt.
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC), accounting for nearly 40% of BC-related deaths. Emerging evidence suggests that the breast tissue microbiome harbors distinct microbial communities; however, the microbiome specific to TNBC remains largely unexplored. This study presents the first comprehensive meta-analysis of the TNBC tissue microbiome, consolidating 16S rRNA amplicon sequencing data from 200 BC samples across four independent cohorts.
View Article and Find Full Text PDFAuxin Gradients Determine Reproductive Development in Pea (Pisum sativum).
Physiol Plant
September 2025
Plant BioSystems, Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Auxins are involved in the regulation of fruit set and development; however, the role of IAA is unclear in pea (Pisum sativum) since the endogenous auxin 4-Cl-IAA appears to be the auxin stimulating ovary (pericarp) growth. To further understand the role of auxins during fruit development, auxin localization, quantitation, transport, and gene expression activity were assessed in this model legume species. IAA levels and auxin activity (DR5::β-Glucuronidase [GUS] staining and enzyme activity) were substantially reduced in the pericarp vascular tissues, pedicels, and peduncles of fruit upon seed removal, reflecting auxin transport streams derived from the seeds through these tissues.
View Article and Find Full Text PDFCuCo-Embedded Nitrogen-Doped Carbon as a Bifunctional Catalyst for Efficient Rechargeable Zinc-Ethanol/Air Batteries.
ACS Appl Mater Interfaces
September 2025
College of Chemistry and Chemical Engineering, Institute of Interdisciplinary Studies, Hunan Normal University, Changsha 410081, China.
The oxygen evolution reaction (OER) in conventional zinc-air batteries (ZABs) involves a complex multielectron transfer process, leading to slow reaction kinetics, high charging voltage, and low energy efficiency. To address these limitations, a zinc-ethanol/air battery (ZEAB) system that strategically replaces the OER with the ethanol oxidation reaction (EOR) possessing a lower thermodynamic potential has been proposed. Herein, a bimetallic catalyst CuCo-embedded nitrogen-doped carbon (CuCo-20%-1), derived from a Cu/Co/Cd co-coordinated metal-organic precursor, is synthesized and exhibits an excellent performance for both EOR and ORR.
View Article and Find Full Text PDFPresenilin loss impairs synaptic transmission and causes axonal degeneration through ryanodine receptor dysfunction, independent of γ-secretase activity.
J Neurosci
September 2025
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, United States.
Presenilin mutations are the most common cause of familial Alzheimer's disease (FAD), but the mechanisms by which they disrupt neuronal function remain unresolved, particularly in relation to γ-secretase activity. Using , we show that the presenilin ortholog SEL-12 supports synaptic transmission and axonal integrity through a pathway involving the ryanodine receptor RYR-1. Loss-of-function mutations in either or reduce neurotransmitter release and cause neuronal structural defects, with no additional impairment in double mutants, suggesting a shared pathway.
View Article and Find Full Text PDF