Publications by authors named "Nour H Marzouk"
Unravelling novel microbial players in the breast tissue of TNBC patients: a meta-analytic perspective.
NPJ Biofilms Microbiomes
September 2025
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC), accounting for nearly 40% of BC-related deaths. Emerging evidence suggests that the breast tissue microbiome harbors distinct microbial communities; however, the microbiome specific to TNBC remains largely unexplored. This study presents the first comprehensive meta-analysis of the TNBC tissue microbiome, consolidating 16S rRNA amplicon sequencing data from 200 BC samples across four independent cohorts.
View Article and Find Full Text PDFParkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by motor dysfunction coupled with gastrointestinal disturbances. Recent studies implicate the gut microbiome with the development of PD, yet pinpointing the exact microbial players is still to be determined. This meta-analysis is the first to consolidate five homogenous case-control studies, covering the same variable regions of the 16S rRNA of 1007 fecal samples.
View Article and Find Full Text PDFArticle Synopsis
- Breast cancer is the leading cancer-related cause of death in women, highlighting the urgent need for new treatment strategies.
- Recent research suggests that reactivating Tumor Suppressor Genes (TSGs) could be a promising intervention by understanding their defects and identifying those under positive selection in mammalian genomes.
- The study identified critical positively selected sites in TSGs like BRCA1 and BRCA2, which are vital for DNA repair, and has developed an automated tool to aid future research on these genetic targets.