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The federated learning (FL) technique can provide a promising solution for the timely training of a deep learning model with the critical requirement of privacy protection. However, the existing FL frameworks still confront challenging issues including heterogeneous data sources, edge device heterogeneity, sensitive information leakage, nonconvex loss, and communication resource constraints which place obstacles in terms of practicality. In this article, first, a federated multitask learning (FedMTL) approach is introduced to reformulate the FL model as a multiobjective optimization problem which results in federated multigradient descent algorithm (FedMGDA) with a better model personalization against data heterogeneity and Byzantine attack. Second, a new semi-asynchronous model aggregation method is developed to asynchronously aggregate small partial clients for compensating impacts of the straggler and staleness. Third, a distributed differential privacy technique is applied to enhance the privacy protection of asynchronous FedMGDA with the convergence guarantee where the convergence analysis of differentially private asynchronous federated multiple gradient descent algorithm (DP-AsynFedMGDA) is studied for both the convex and the nonconvex loss functions. Empirical examples and comparative studies are presented to illustrate the effectiveness of the proposed DP-AsynFedMGDA.
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http://dx.doi.org/10.1109/TCYB.2025.3571953 | DOI Listing |
Front Digit Health
August 2025
KASTEL Security Research Labs, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
In medical environments, time-continuous data, such as electrocardiographic records, necessitates a distinct approach to anonymization due to the paramount importance of preserving its spatio-temporal integrity for optimal utility. A wide array of data types, characterized by their high sensitivity to the patient's well-being and their substantial interest to researchers, are generated. A significant proportion of this data may be of interest to researchers beyond the original purposes for which it was collected.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Fujian Psychiatric Center, Fujian Clinical Research Center for Mental Disorders, Xianyue Hospital Affiliated to Xiamen Medical College, Xiamen, China.
Background: In the digital health era, telemedicine has become a key driver of health care reform and innovation globally. Understanding the factors influencing residents' choices of telemedicine services is crucial for optimizing service design, enhancing user experience, and developing effective policy measures.
Objective: This study aims to explore the key factors influencing Chinese residents' choices of telemedicine services, including consultation fee, physician qualifications, appointment waiting time, scope of services, privacy protection, and service hours.
Bioinform Adv
August 2025
Department of Anatomy and Cell Biology, Medical School OWL, Bielefeld University, Bielefeld 33615, Germany.
Motivation: The growing use of transcriptomic data from platforms like Nanostring GeoMx DSP demands accessible and flexible tools for differential gene expression analysis and heatmap generation. Current web-based tools often lack transparency, modifiability, and independence from external servers creating barriers for researchers seeking customizable workflows, as well as data privacy and security. Additionally, tools that can be utilized by individuals with minimal bioinformatics expertise provide an inclusive solution, empowering a broader range of users to analyze complex data effectively.
View Article and Find Full Text PDFArtif Intell Med
November 2025
Department of Nuclear Medicine, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, 313001, China. Electronic address:
Positron Emission Tomography-Computed Tomography (PET-CT) evolution is critical for liver lesion diagnosis. However, data scarcity, privacy concerns, and cross-institutional imaging heterogeneity impede accurate deep learning model deployment. We propose a Federated Transfer Learning (FTL) framework that integrates federated learning's privacy-preserving collaboration with transfer learning's pre-trained model adaptation, enhancing liver lesion segmentation in PET-CT imaging.
View Article and Find Full Text PDFHum Reprod Open
August 2025
Biology of the Testis (BITE) Laboratory, Genetics, Reproduction and Development (GRAD) Research Group, Vrije Universiteit Brussel, Brussels, Belgium.
Study Question: Can testicular tissue from trans women (trans tissue) be used to create human testicular organoids?
Summary Answer: Testosterone-producing and cytotypic human testicular organoids with bicompartmental architecture can be successfully generated from trans tissue.
What Is Known Already: Testicular organoids are a promising tool for studying testicular function and the effects of toxicants. Immature testicular cells are currently the most efficient at forming organoids that closely recapitulate seminiferous tubule-like architecture and functions.