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Introduction: Undiagnosed diabetes is associated with lack of insurance, which decreases access to preventive care. During the COVID-19 pandemic, uninsured patients previously unknown to health systems were hospitalized.
Methods: This is a cross-sectional analysis of electronic health record data from patients with diabetes hospitalized with COVID-19 in a safety-net health system from June 2020 to December 2021, examining the association between payor status and incident diagnosis of diabetes. Incident diagnosis of diabetes was defined by excluding a prior known diagnosis of diabetes based on diagnosis codes, medications, and HgbA1c from the past 5 years. Regression analysis evaluated the association between payor status and incident diagnosis of diabetes. Data were analyzed in 2023.
Results: Among 872 patients with diabetes hospitalized with COVID-19, 24.0% were uninsured, 34.6% received county-funded charity coverage, 17.1% received Medicaid, and 24.3% received Medicare. The rate of incident diagnosis of diabetes in the total sample was 20.3%; incident diagnosis of diabetes was more common among the uninsured (30.1%) than among county-funded charity coverage (18.2%) and Medicare (11.3%) patients. After adjusting for age, gender, race/ethnicity, and BMI, uninsured patients had higher odds of incident diagnosis of diabetes (AOR=2.64; 95% CI=1.41, 4.92; p=0.002) than Medicare patients. Odds of incident diagnosis of diabetes were similar for county-funded charity coverage and Medicare patients.
Conclusions: Uninsured patients had higher odds of incident diagnosis of diabetes during COVID-19 hospitalization that may have gone undetected without hospitalization. These findings reflect decreased access to preventive care and missed opportunities to screen for diabetes among the uninsured.
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http://dx.doi.org/10.1016/j.amepre.2025.107949 | DOI Listing |
Diabetes Metab Res Rev
September 2025
Department of Nephrology, Daping Hospital, Army Medical University, Chongqing, China.
Chronic kidney disease (CKD) substantially increases cardiovascular risk, with endothelial dysfunction as its central pathological mechanism. This review summarises the molecular regulatory mechanisms underlying endothelial dysfunction in CKD and highlights recent advances in treatment strategies. The pathophysiology of endothelial injuries involves a complex network of multiple factors and mechanisms, including oxidative stress, inflammation, glycocalyx damage, ischaemia, hypoxia, cellular senescence and endothelial-mesenchymal transition (EndMT).
View Article and Find Full Text PDFDiabetes Metab Res Rev
September 2025
Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', Bari, Italy.
Overweight and obesity represent common chronic metabolic disorders in the general population, and observed trends describe a substantial growth in the prevalence of weight excess also among individuals with type 1 diabetes (T1D), the so-called 'lean phenotype' of diabetes. The sharp rise of weight excess and obesity-related cardio-nephron-metabolic burdens observed in T2D is expected to produce similar consequences in T1D, leading to the urgent need to endorse therapeutic protocols as in most parts of the World no adjunctive treatments are approved for T1D, making weight excess management challenging in these individuals. The notable results shown by newer glucagon-like peptide 1 receptor agonists (GLP-1RAs) and emerging dual agonists, especially while managing cardio-metabolic burdens, in T2D have encouraged fervent anecdotal and non-anecdotal research also in T1D, indicating that non-insulin injective agents can be effective and safe.
View Article and Find Full Text PDFAnal Bioanal Chem
September 2025
Center for Clinical Mass Spectrometry, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Latent autoimmune diabetes in adults (LADA) is a slowly progressing form of diabetes that develops in adulthood, characterized by autoimmune destruction of pancreatic β-cells and subsequent insulin deficiency, akin to type 1 diabetes (T1D). Due to its shared genetic, immunological, and metabolic features with both T1D and type 2 diabetes (T2D), LADA is frequently misdiagnosed and inappropriately treated as T2D. To address this, we developed the A.
View Article and Find Full Text PDFInt J Cardiol
September 2025
Federico II University, Naples, Italy; Federico II University Hospital, Naples, Italy. Electronic address:
Background: Peripartum cardiomyopathy (PPCM) is a rare, life-threatening form of heart failure occurring in late pregnancy or postpartum, with variable clinical course and outcomes. We report preliminary clinical and echocardiographic findings from a national Italian registry of PPCM patients METHODS: The study was approved by the institutional Ethics Committee and registered at ClinicalTrials.gov (NCT05878041).
View Article and Find Full Text PDFDiabetes Res Clin Pract
September 2025
Université Paris Cité, ECEVE, UMR 1123, Inserm, F-75010 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de santé publique, équipe REPERES, F-75019 Paris, France. Electronic address:
Aims: To study the association between socioeconomic status (SES) and hospital efficiency in Type 1 diabetes mellitus patients admitted for ketoacidosis or diabetic coma in mainland France, overall and in adults versus children.
Methods: An observational study was carried out using exhaustive national hospital discharge databases. It included all admissions discharged from 2013 to 2019.