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Purpose: This study reports the implementation of a proof-of-concept, artificial intelligence (AI)-driven clinical decision support system for detecting nystagmus. The system collects and analyzes real-time clinical data to assist in diagnosing, demonstrating its potential for integration into telemedicine platforms. Patients may benefit from the system's convenience, reduced need for travel and associated costs, and increased flexibility and increased flexibility through both in-person and virtual applications.
Methods: A bedside clinical test revealed vertigo during rightward body movement, and the patient was referred for videonystagmography (VNG). The VNG showed normal central ocular findings. During the right Dix-Hallpike maneuver, the patient demonstrated rotatory nystagmus accompanied by vertigo. Caloric tests revealed symmetric responses, with no evidence of unilateral or bilateral weakness. A cloud-based deep learning framework was developed and trained to track eye movements and detect 468 distinct facial landmarks in real time. Ten subjects participated in this study.
Results: The slow-phase velocity (SPV) value was verified for statistical significance using both VNG machine-generated graphs and clinician assessment. The average SPV was compared to the value generated by the VNG machine. The calculated statistical values were as follows: p < 0.05, a mean squared error of 0.00459, and a correction error of ±4.8%.
Conclusion: This deep learning model demonstrates the potential to provide diagnostic consultation to individuals in remote locations. To some extent, it may supplement or partially replace traditional methods such as VNG. Ongoing advancements in machine learning within medicine will enhance the ability to diagnose patients, facilitate appropriate specialist referrals, and support physicians in post-treatment follow-up. As this was a proof-of-concept pilot study, further research with a larger sample size is warranted.
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http://dx.doi.org/10.7759/cureus.84036 | DOI Listing |
BMC Neurol
September 2025
Department of Neurology, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, Aachen, North Rhine-Westphalia, Germany.
Background: Cerebellar pathologies in adults can have a wide range of hereditary, acquired and sporadic-degenerative causes. Due to the frequency in daily hospital, especially intensive care, settings, electrolyte imbalances are an important, yet rare differential diagnosis. The hypomagnesemia-induced cerebellar syndrome (HiCS) constitutes a relevant disease entity with clinical and morphological variability due to a potential progression of symptoms and a promising causal treatment.
View Article and Find Full Text PDFInt J Ophthalmol
September 2025
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.
Aim: To detect and segregate causative mutations in congenital families with optic nerve hypoplasia (ONH).
Methods: Two unrelated consanguineous Pakistani families with severe ONH, showing features of micropthalmia, nystagmus, corneal opacity, and keratopathy were included. Genetic analysis was carried out by Target Panel Sequencing, and the nucleotide variant was confirmed by Sanger sequencing.
J Neuroophthalmol
August 2025
Temerty Faculty of Medicine (DM), University of Toronto, Toronto, Canada; Department of Ophthalmology and Vision Sciences (MB, JAM), University of Toronto, Toronto, Canada; Division of Neurology (JAM), Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada; Kensington
Background: Multimodal artificial intelligence (AI) models have recently expanded into video analysis. In ophthalmology, one exploratory application is the automated detection of extraocular movement (EOM) disorders. This proof-of-concept study evaluated the feasibility of using Gemini 2.
View Article and Find Full Text PDFJ Hum Genet
August 2025
Molecular Genetics Laboratory, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Spinocerebellar ataxia (SCA27B), due to an intronic GAA repeat expansion in the FGF14 gene, has been described recently. We screened DNA samples for expanded FGF14 GAA repeats in individuals with movement disorder (N = 526) in our laboratory at NIMHANS, Bengaluru, India. Clinically pathogenic repeat expansions of FGF14 (GAA) were detected in 14 of 526 patients (2.
View Article and Find Full Text PDFEur J Med Res
August 2025
Institute of Nutrition and Diseases and Center for Research, School of Public Health, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Introduction: A significant portion of patients with acute vestibular syndrome (AVS) due to posterior circulation infarction (PCI) is free of non-vestibular signs. A differential diagnosis of this form from that due to vestibular neuritis (VN) can be challenging. We herein aimed to understand whether quantitative eye movement signature could be used to assist such a diagnosis.
View Article and Find Full Text PDF