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In this paper, we investigate the performance of a high-power confined doped fiber amplifier to achieve high power and high beam quality. The impact of various factors, including core diameter, doping ratio, and numerical aperture, on the gain-tailoring effect is explored to establish fiber parameters for attaining near single mode beam quality at high power, taking into account variations in coiling diameters. Based on simulation results, a confined doped fiber with a low numerical aperture, featuring a core/cladding diameter of 30/250 μm and a relative doping ratio of 0.8, was fabricated in-house and utilized in a tandem-pumped fiber amplifier. The experimental results coincide well with the simulation results except for discrepancies arising from the imperfect refractive index profile of the fiber. An output power of 7.2 kW with the M factor of 1.55 was obtained. This work can provide guidelines for designing 10 kW level single-mode fiber lasers employing confined doped fiber.
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http://dx.doi.org/10.1364/OE.561925 | DOI Listing |
Mater Today Bio
October 2025
School of Public Health, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University, Haikou, 571199, China.
The development of controllable nanoplatforms with disease-specific responsiveness and programmable therapeutic functions is vital for treating complex cardiovascular diseases such as atherosclerosis. Herein, we present an intelligent, next-generation nanoplatform (HALA@AgS) that integrates enzyme-responsive dual-drug delivery with NIR-II imaging-guided photothermal therapy (PTT), enabling triple-stimuli synergy of enzyme, light, and multi-drug co-activation. This modular design enables stable nanoassemblies with high drug-loading capacity and selective disassembly in enzyme-rich plaque microenvironments, achieving controlled dual-drug release exceeding 80 % within 72 h.
View Article and Find Full Text PDFInt Immunopharmacol
September 2025
Institutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, Shanxi Province, China. Electronic address:
Butyrate is a short-chain fatty acid produced by intestinal bacteria during the fermentation of dietary fibers and has shown potential in modulating inflammatory responses. Herein, we investigated how sodium butyrate exerts dual, dose-dependent regulation of innate immunity using the zebrafish model of lipopolysaccharide (LPS)-induced inflammation. Our results demonstrated that at low concentrations (3 mM), sodium butyrate suppressed LPS-driven pro-inflammatory mediators (il1β, cebpβ, irg1l) while restoring anti-inflammatory and tissue-repair genes (lyz, il8, elf3).
View Article and Find Full Text PDFRev Sci Instrum
September 2025
Institut für Physik, Universität Osnabrück, Barbarastr. 7, 49076 Osnabrück, Germany.
An interferometer used for displacement measurement is typically adjusted to the center or another appropriate point of the interferometer fringe as a working point to yield maximum detection sensitivity and linearity. The interferometer is prone to varying misalignment in the course of measurements, most noticeable due to thermal drift affecting the interferometer dimensions. We introduce an automatic correction mechanism based on a proportional/integral (PI) control loop to remove any error in the alignment of the fiber interferometer, specifically long-term drift.
View Article and Find Full Text PDFPain
September 2025
Division of Neurophysiology, Center for Brain Research, Medical University of Vienna, Wien, Austria.
Astrocytes are key players in chronic pain, driving maladaptive changes in neuronal circuits. Yet, their influence on acute nociception-the body's first line of defense against harmful stimuli-remains poorly understood. Using chemogenetic tools to mimic endogenous astrocytic G-protein-coupled receptor-mediated signaling, we reveal that astrocytes induce bidirectional plasticity at nociceptive synapses in the dorsal horn.
View Article and Find Full Text PDFJ Phys Chem B
September 2025
São Carlos Institute of Chemistry (IQSC), University of São Paulo (USP), São Carlos, SP 13560-970, Brazil.
RNA amplification is central to viral diagnostics, yet current optical and fluorometric methods, such as PCR and RT-qPCR, remain costly, complex, and resource-intensive. Here, we introduce differential capacitance spectroscopy (DCS) as a real-time electrochemical method for RNA detection using loop-mediated isothermal amplification. By applying sinusoidal currents to flexible carbon fiber electrodes (0.
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