Publications by authors named "Rui-Zhu Shi"
Impact of sodium butyrate on lipopolysaccharide-induced inflammatory response in zebrafish.
Int Immunopharmacol
September 2025
Butyrate is a short-chain fatty acid produced by intestinal bacteria during the fermentation of dietary fibers and has shown potential in modulating inflammatory responses. Herein, we investigated how sodium butyrate exerts dual, dose-dependent regulation of innate immunity using the zebrafish model of lipopolysaccharide (LPS)-induced inflammation. Our results demonstrated that at low concentrations (3 mM), sodium butyrate suppressed LPS-driven pro-inflammatory mediators (il1β, cebpβ, irg1l) while restoring anti-inflammatory and tissue-repair genes (lyz, il8, elf3).
View Article and Find Full Text PDFArticle Synopsis
- Porcine hemagglutinating encephalomyelitis virus (PHEV) causes neurological symptoms in pigs and is found globally, but it has been understudied despite being one of the earliest porcine coronaviruses identified.
- The full genome of the first US PHEV strain from 1970 was sequenced in 2020, enabling a comparative analysis of PHEV strains from 1970 to 2015.
- The study revealed significant genetic changes in recent US and Belgian strains, including multiple deletions and variability in the spike glycoprotein, suggesting genetic drift that could impact PHEV monitoring worldwide.
Swine acute diarrhea syndrome (SADS) is a highly contagious infectious disease characterized by acute vomiting and watery diarrhea in neonatal piglets. The causative agent for SADS is the swine acute diarrhea syndrome coronavirus (SADS-CoV), an alphacoronavirus in the family . Currently, SADS-CoV was identified only in Guangdong and Fujian provinces of China, not in any other regions or countries in the world.
View Article and Find Full Text PDFThe porcine epidemic diarrhea virus (PEDV) causes a highly contagious disease in pigs, which is one of the most devastating viral diseases of swine in the world. In China, PEDV was first confirmed in 1984 and PEDV infections occurred sporadically from 1984 to early 2010. From late 2010 until present, PEDV infections have swept every province or region in China.
View Article and Find Full Text PDFArticle Synopsis
- MERS is an illness caused by the MERS-CoV virus, which affects both humans and camels, with camels thought to be a key source for human infections, though many initial cases lack clear origins.
- Researchers discovered two important conserved nucleotides in the virus's genetic structure that categorize MERS-CoV into three types: UUAAUU, CUAAUU, and CUAAUC, indicating variations in the virus's evolution.
- Between 2012 and 2019, the human version of MERS-CoV underwent a genetic shift from the U type to the C type, while camels showed a similar shift but with a delay, suggesting that camels may not be the sole natural reservoir for human infections
The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell. RHA is also hijacked by a variety of RNA viruses to facilitate virus replication.
View Article and Find Full Text PDF