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Quantum random number generators (QRNGs) leverage the inherent unpredictability of quantum mechanical phenomena to produce random numbers. However, the performance of many QRNGs is hindered by limitations such as low generation rates and the bulkiness of systems utilizing single-photon detectors (SPDs). In this study, we present a QRNG that addresses these challenges by using a micro-LED as an entropy source, utilizing the intensity fluctuations of spontaneous emissions. By applying post-processing techniques, our 5 × 5 µm micro-LED-based system achieves a PD bandwidth-limited generation rate of 9.375 Gbit/s while successfully passing the required randomness tests outlined by the National Institute of Standards and Technology (NIST). Importantly, systematic testing across micro-LEDs of varying sizes demonstrates consistently high performance, highlighting the robustness of this approach. The compact, small footprint, scalable design, and surface emission characteristics of micro-LEDs pave the way for the development of parallel QRNG-integrated chips, which hold the potential to deliver ultra-high random number generation rates in practical, miniaturized platforms.
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http://dx.doi.org/10.1364/OE.559375 | DOI Listing |
JAMA Surg
September 2025
Department of Surgery, Meander Medical Center, Amersfoort, the Netherlands.
Importance: Stoma reversal is associated with few complications. However, recent studies show that 1 in 3 patients develop an incisional hernia, for which half of the patients receive surgical correction.
Objective: To investigate whether prophylactic synthetic mesh placement in the retromuscular space during stoma reversal reduces the rate of stomal site incisional hernias.
Eur J Clin Microbiol Infect Dis
September 2025
Department of Infectious and Tropical Diseases, Toulouse University Hospital, Toulouse, 31059 Cedex 9, France.
Purpose: This narrative review aims to provide an overview of current knowledge on mpox, emphasizing updated epidemiology and recent advances in treatment and prevention strategies, in light of the latest outbreaks.
Methods: We searched PubMed and Google Scholar for publications on 'Mpox' and 'Monkeypox' up to June 5, 2025. Grey literature from governmental and health agencies was also accessed for outbreak reports and guidelines where published evidence was unavailable.
Inflammopharmacology
September 2025
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background: Pentoxifylline (PTX), a methylxanthine derivative, has been recognized as a potential anti-inflammatory treatment across various conditions, yet its effects on inflammatory markers remain inconsistent. This systematic review/meta-analysis evaluated the impact of PTX on serum levels and gene expression of key inflammatory markers in randomized controlled trials (RCTs).
Methods: A systematic search was conducted in PubMed, Scopus, Embase, Web of Science, and ProQuest up to May 2025.
Eur J Orthop Surg Traumatol
September 2025
All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India.
Background: Pelvic and acetabular fractures, often resulting from high-impact trauma, pose significant challenges due to extensive blood loss and complex surgical procedures. Tranexamic acid (TXA), widely used in elective orthopedic surgeries, offers a potential strategy for managing blood loss. However, its efficacy and safety in pelvic-acetabular trauma surgeries have shown inconsistent results in prior studies.
View Article and Find Full Text PDFJ Glaucoma
September 2025
Department of Ophthalmology, University of Campinas, Campinas, São Paulo, Brazil.
Prcis: Gonioscopy-Assisted Transluminal Trabeculotomy achieved a higher success rate than Bent Ab interno Needle Goniotomy in pseudophakic primary open angle glaucoma eyes at 12-months.
Purpose: To evaluate and compare efficacy and safety of standalone Bent Ab interno Needle Goniotomy (BANG) and Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) in pseudophakic primary open angle glaucoma (POAG) eyes.
Methods: Parallel, double-arm, 1:1 ratio, single masked, single surgeon, randomized clinical trial.