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Article Abstract
Candida albicans causes systemic infections with 20-50% mortality in critically ill and immunocompromised patients, despite antifungal treatment. Current therapies face limitations, including toxicity and resistance, underscoring the need for prophylactic vaccines. This study presents a novel divalent liposomal vaccine, delivering C. albicans Cht3 and Sap2 antigens. Vaccination induced protective Th1/Th17 immunity, a balanced Th1/Th2 ratio, antigen-specific antibodies, and boosted macrophage activity, improving survival in a mouse model of invasive candidiasis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166040 | PMC |
| http://dx.doi.org/10.1038/s41541-025-01183-0 | DOI Listing |
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