98%
921
2 minutes
20
Andean plants are rich in bioactive compounds shaped by extreme environmental conditions, contributing to their antioxidant, antimicrobial, and anti-inflammatory properties. This review explores their phytochemical composition, biological activities, and therapeutic potential in modern medicine and nutrition of three plants of Andean origin. A literature review of peer-reviewed studies was conducted, focusing on key species such as quinoa (), amaranth ( spp.), and lupin ( spp.), selected for this review due to their Andean origin, long-standing role in traditional diets, and growing scientific interest in their unique phytochemical profiles and therapeutic potential. This analysis covers their phytochemistry, bioactivities, and the influence of environmental factors on compound potency. These Andean-origin plants contain flavonoids, terpenoids, alkaloids, and phenolic compounds that support antioxidant, antimicrobial, anti-inflammatory, and anticancer activities. High-altitude conditions enhance the biosynthesis of these bioactives, increasing their therapeutic value. Quinoa, amaranth, and lupin show strong potential for dietary and pharmaceutical applications, particularly in metabolic health and disease prevention. Additionally, preclinical studies and clinical trials have begun exploring the efficacy of these compounds in preventing and treating metabolic and chronic diseases. Andean plants are a valuable source of functional bioactive molecules with diverse health benefits. Future research should optimize cultivation strategies and explore novel applications in nutrition and medicine.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12157067 | PMC |
http://dx.doi.org/10.3390/nu17111749 | DOI Listing |
Crit Rev Immunol
January 2025
Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Dist. Medchal,500078, Telangana State, India.
Caseinolytic protease P (ClpP) is a highly conserved serine protease that plays a pivotal role in protein homeostasis and quality control in bacteria, mitochondria of mammalian cells, and plant chloroplasts. As the proteolytic core of the ATP-dependent Clp protease complex, ClpP partners with regulatory ATPases (e.g.
View Article and Find Full Text PDFCrit Rev Immunol
January 2025
Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Dist. Medchal,500078, Telangana State, India.
IL-2 agonists significantly modulate T cell regulation, impacting activation, proliferation, differentiation, and immune homeostasis. Interleukin-2 (IL-2) is crucial for T cell growth and function, binding to the IL-2 receptor to trigger signaling pathways that balance immune responses. IL-2 promotes the expansion of effector T cells and enhances regulatory T cells (Tregs), preventing autoimmune responses.
View Article and Find Full Text PDFCrit Rev Immunol
January 2025
Department of General Surgery, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China.
Objective: This study aimed to probe the role of Shenling Baizhu powder (SLBZP) in inhibiting breast cancer (BC) lung metastasis, focusing on epithelial-to-mesenchymal transition (EMT) and ferroptosis.
Methods: BC 4T1 cells were treated with low (3.13 µg/mL) and high (12.
Crit Rev Immunol
January 2025
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.
Stemming from human immune organs, tonsil-derived mesenchymal stem cells (TMSCs) hold unique strengths in differentiation potential and immune regulatory functions. These characteristics make them valuable for therapeutic applications, particularly in regenerative medicine and autoimmune disease treatment, as they can modulate immune responses and promote tissue repair. Their ability to interact with various cell types and secrete a range of bioactive molecules further enhances their role in orchestrating healing processes, making them a promising avenue for innovative therapies aimed at restoring balance in the immune system and facilitating recovery from injury or disease.
View Article and Find Full Text PDFJ Environ Pathol Toxicol Oncol
January 2025
Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Despite advancements in systemic therapy, the mortality rate for patients with metastatic melanoma remains around 70%, underscoring the imperative for alternative treatment strategies. Through the establishment of a chemoresistant melanoma model and a subsequent drug investigation, we have identified pacritinib, a medication designed for treating myelofibrosis and severe thrombocytopenia, as a potential candidate to overcome resistance to melanoma therapy. Our research reveals that pacritinib, administered at clinically achievable concentrations, effectively targets dacarbazine-resistant melanoma cells by suppressing IRAK1 rather than JAK2.
View Article and Find Full Text PDF