98%
921
2 minutes
20
To compare the efficacy of the "double-strand inverted V-shape" vs the "single-strand looped" suture techniques to treat acetabular labral injuries under hip arthroscopy. In this study, clinical data of patients diagnosed with femoroacetabular impingement admitted to the Department of Sports Medicine, Orthopedic Medicine Division, the Chinese PLA General Hospital from June 2018 to July 2022 were collected and analyzed retrospectively. Patients were divided into the "double-strand inverted V-shape" (double-strand) and the "single-strand looped" (single-strand) groups based on the surgical suture method for the injured labrum. The two groups were compared in terms of the labral injury extent, number and cost of anchors, and preoperative and postoperative outcomes using the visual analog scale (VAS) for pain, modified Harris Hip score (mHHS), and International Hip Outcome Tool (iHOT-12) scores. Fifty-eight patients were included, with 30 in the double-strand group, 20 males and 10 females, aged (37.8±10.2) years, and 28 in the single-strand group, 18 males and 10 females, aged (39.3±12.6) years. All patients underwent surgery successfully, and the patients in the double-strand group and single-strand group were followed-up for [(, )] [36.0(24.0, 36.0) and 30.0(24.0, 36.0) months, respectively. The extent of labral injury 3.5 (3.0, 4.0) vs 2.0 (1.5, 2.4) h], the number of anchors [4.0 (4.0, 4.3) vs 3.0 (3.0, 4.0) pins], and the cost of the anchors [7 084 (6 916, 8 603) vs 5 061 (5 061, 6 748) yuan] in the double-strand group were all higher than those of the single-strand group (all <0.001), but the number of anchors/injury extent [1.2 (1.1, 1.3) vs. 1.5 (1.5, 2.0) pins/h] and anchor cost/injury extent[2 092 (1 949, 2 305) vs. 2 531 (2 531, 3 374) yuan/h] were lower (both <0.001). There was no statistical significance in the differences of preoperative and postoperative VAS, mHHS, and iHOT scores between the double-strand group and the single-strand group, as well as in the differences of the changes in VAS, mHHS, and iHOT scores before and after surgery (all >0.05). The "double-strand inverted V-shape" suture technique for acetabular labral injuries under hip arthroscopy can achieve clinical outcomes similar to the "single-strand looped" suture technique while reducing anchor use and costs under same injury extent, and providing better economic benefits.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.3760/cma.j.cn112137-20241218-02872 | DOI Listing |
bioRxiv
August 2025
PRC, UMR INRAe 0085, CNRS 7247, Centre INRAe Val de Loire, 37380, Nouzilly, France.
PGBD5 is encoded by a gene domesticated at the chordate origin from a DNA transposon of the family. During its evolution, PGBD5's sequence has been under strong purifying selection among vertebrate genomes. This suggests PGBD5 functions in the development and physiology of chordates, as recently demonstrated in mouse and human brain development, where it was implicated in double strand DNA breaks on neurons.
View Article and Find Full Text PDFZhonghua Yi Xue Za Zhi
July 2025
Department of Sports Medicine, Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
To compare the efficacy of the "double-strand inverted V-shape" vs the "single-strand looped" suture techniques to treat acetabular labral injuries under hip arthroscopy. In this study, clinical data of patients diagnosed with femoroacetabular impingement admitted to the Department of Sports Medicine, Orthopedic Medicine Division, the Chinese PLA General Hospital from June 2018 to July 2022 were collected and analyzed retrospectively. Patients were divided into the "double-strand inverted V-shape" (double-strand) and the "single-strand looped" (single-strand) groups based on the surgical suture method for the injured labrum.
View Article and Find Full Text PDFPhys Med
July 2025
Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiotherapy, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, the Netherlands; Department of Vascular Surgery, Erasm
Background And Purpose: Proton-induced cell death is primarily driven by the induction and repair of DNA double strand breaks. While DNA damage dynamics have been extensively studied, the early cellular responses to proton irradiation remain underexplored. To address this, we developed a novel live-cell microscopy platform that enables real-time visualization of cellular responses to DNA damage induced by proton therapy.
View Article and Find Full Text PDFAm J Med Genet A
July 2025
Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan.
Duplication-triplication/inverted-duplication (DUP-TRP/INV-DUP) is one of the mechanisms that causes genomic triplications. There are some characteristics of the DUP-TRP/INV-DUP; the appearance of a moving average of signal log2 ratio in genomic copy number analysis consisting of the highest center with lower steps on both sides; the chromosomal structure is composed of only two junctions; there are inverted repeats at the ends of the triplications and duplications on the same side and those connected in the opposite direction; and the size of the DUP-TRP/INV-DUP structure is generally less than the 1-Mb range. In this study, we analyzed two patients with DUP-TRP/INV-DUP involving PLP1 and MECP2.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA.
Formation of templated insertions at DNA double-strand breaks (DSBs) is very common in cancer cells. The mechanisms and enzymes regulating these events are largely unknown. Here, we investigated templated insertions in yeast at DSBs using amplicon sequencing across a repaired locus.
View Article and Find Full Text PDF