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Background: State policies requiring clinicians to review prescription drug monitoring program (PDMP) databases have proliferated. Patient advocates warn that such policies may reduce quality of life for some patients.
Objectives: To quantify the relationship between must-access PDMPs and pain and physical impairment outcomes.
Research Design: Using Health and Retirement Survey (HRS) data on older adults in the US from 2002-2021, we conducted a heterogeneity-robust difference-in-differences analysis.
Results: The population included 34,431 individuals with an average age of 67. Must-access PDMPs were initially associated with 1.65 (95% CI: 0.43 - 2.87) to 3.52 (95% CI: 0.88 - 6.16) percentage point increases in the reports of frequent pain. However, the effect dissipated over time. Effects on the impairment outcomes were positive but statistically insignificant.
Conclusions: Must-access PDMP policies are associated with an initial increase in frequent pain reported by older adults. No significant effects on physical impairment outcomes were found. Continued research examining the role of PDMPs on patient health outcomes is warranted.
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http://dx.doi.org/10.1101/2025.06.02.25328258 | DOI Listing |
Expert Rev Med Devices
September 2025
Department of Physical Medicine and Rehabilitation, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Rae Bareli Road, Lucknow, Uttar Pradesh, INDIA 226014.
Introduction: The World Health Organization (WHO) reported in 2023 that approximately 1.3 billion people, or 16% of the global population, are living with a disability. Among these, locomotor disabilities constitute a significant portion, underscoring the urgent need for devices that enhance mobility and support daily living.
View Article and Find Full Text PDFBrain Behav
September 2025
School of Physical Education and Health, Henan University of Chinese Medicine, Zhengzhou, China.
Background: Clinical and basic research suggests that exercise is a safe behavioral intervention and effective in improving cognition in vascular dementia (VD). However, despite global efforts, there is still no effective method to completely cure VD. This study aimed to investigate the effects of long-term exercise pretreatment on typical VD pathology in a rat model, and further compare the neuroprotective impacts of different exercise modalities on VD rats.
View Article and Find Full Text PDFJPEN J Parenter Enteral Nutr
September 2025
Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan.
Background: Limited evidence exists regarding the cognitive and physical improvement effects of medium-chain triglyceride (MCT) intake in patients with stroke. This study aimed to investigate the association between MCT-enhanced rice consumption and enhancements in outcomes, including cognitive level, in patients following stroke.
Methods: We performed a retrospective cohort study on adults admitted to a rehabilitation center with cognitive decline following acute stroke.
Lab Anim Res
September 2025
Department of Pathology, Faculty of Medicine, Kindai University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.
Background: Stroke-prone spontaneously hypertensive rats (SHRSP) exhibit slow-twitch muscle-specific hypotrophy compared with normotensive Wistar-Kyoto rats (WKY). Because slow-twitch muscles are prone to disuse atrophy, SHRSP may experience both disuse atrophy and impaired recovery from it. This study investigated the response of SHRSP to disuse atrophy and subsequent recovery, using WKY as a control.
View Article and Find Full Text PDFPediatr Exerc Sci
September 2025
Division of Movement Science and Exercise Therapy, Department of Exercise, Sport and Lifestyle Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch,South Africa.
Background: Juvenile idiopathic arthritis is an autoimmune condition of multifactorial etiology resulting in chronic inflammatory joint disease, which may be associated with systemic manifestations. Therapeutic exercise is essential to counteract physical impairments, which requires the implementation of outcome measures (OMs) in research and practice as they provide meaningful results for research efficacy, exercise program evaluation and quality, medication tolerance, and patient improvement.
Purpose: To assess the types of OMs implemented in exercise randomized controlled trials related to the juvenile idiopathic arthritis cohort and the psychometric properties and age appropriateness of the implemented OMs.