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Accurate traffic flow prediction is vital for intelligent transportation systems but presents significant challenges. Existing methods, however, have the following limitations: (1) insufficient exploration of interactions across different temporal scales, which restricts effective future flow prediction; (2) reliance on predefined graph structures in graph neural networks, making it challenging to accurately model the spatial relationships in complex road networks; and (3) end-to-end training, which often results in unclear optimization directions for model parameters, thereby limiting improvements in predictive performance. To address these issues, this paper proposes a non-end-to-end adaptive graph learning algorithm capable of effectively capturing complex dependencies. The method incorporates a multi-scale temporal attention module and a multi-scale temporal convolution module to extract multi-scale information. Additionally, a novel graph learning module is designed to adaptively capture potential correlations between nodes during training. The parameters of the prediction and graph learning modules are alternately optimized, ensuring global performance improvement under locally optimal conditions. Furthermore, the graph structure is dynamically updated using a weighted summation approach.Experiments demonstrate that the proposed method significantly improves prediction accuracy on the PeMSD4 and PeMSD8 datasets. Ablation studies further validate the effectiveness of each module, and the rationality of the graph structures generated by the graph learning module is visually confirmed, showcasing excellent predictive performance.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12157338 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0322145 | PLOS |
Proc Mach Learn Res
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Pretraining plays a pivotal role in acquiring generalized knowledge from large-scale data, achieving remarkable successes as evidenced by large models in CV and NLP. However, progress in the graph domain remains limited due to fundamental challenges represented by feature heterogeneity and structural heterogeneity. Recent efforts have been made to address feature heterogeneity via Large Language Models (LLMs) on text-attributed graphs (TAGs) by generating fixed-length text representations as node features.
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August 2025
Engineering Research Center of Cell & Therapeutic Antibody (MOE), School of Pharmacy, Shanghai Jiao Tong University Shanghai 200240 China
Predicting Antibody-Antigen (Ab-Ag) docking and structure-based design represent significant long-term and therapeutically important challenges in computational biology. We present SAGERank, a general, configurable deep learning framework for antibody design using Graph Sample and Aggregate Networks. SAGERank successfully predicted the majority of epitopes in a cancer target dataset.
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August 2025
Physiology, SGT University, Gurugram, IND.
Introduction Simulation-based training has been a vital part of medical education since Competency-Based Medical Education (CBME) was introduced, and new guidelines since 2023 have expanded to include simulation as a mandatory methodology of teaching. This method enables learners to build and develop both technical and non-technical abilities in a safe and controlled setting, enhancing their preparedness for real-life medical scenarios. Simulation-based training improves skill acquisition and retention and enhances learners' confidence, reduces anxiety, reinforces learning, corrects errors, and promotes reflective practice, in contrast with the traditional method of teaching.
View Article and Find Full Text PDFComput Med Imaging Graph
August 2025
Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China. Electronic address:
Bipolar disorder (BD) is a debilitating mental illness characterized by significant mood swings, posing a substantial challenge for accurate diagnosis due to its clinical complexity. This paper presents CS2former, a novel approach leveraging a dual channel-spatial feature extraction module within a Transformer model to diagnose BD from resting-state functional MRI (Rs-fMRI) and T1-weighted MRI (T1w-MRI) data. CS2former employs a Channel-2D Spatial Feature Aggregation Module to decouple channel and spatial information from Rs-fMRI, while a Channel-3D Spatial Attention Module with Synchronized Attention Module (SAM) concurrently computes attention for T1w-MRI feature maps.
View Article and Find Full Text PDFNat Biomed Eng
September 2025
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Phenotype-driven approaches identify disease-counteracting compounds by analysing the phenotypic signatures that distinguish diseased from healthy states. Here we introduce PDGrapher, a causally inspired graph neural network model that predicts combinatorial perturbagens (sets of therapeutic targets) capable of reversing disease phenotypes. Unlike methods that learn how perturbations alter phenotypes, PDGrapher solves the inverse problem and predicts the perturbagens needed to achieve a desired response by embedding disease cell states into networks, learning a latent representation of these states, and identifying optimal combinatorial perturbations.
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