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Article Abstract
Covering: up to 2025Natural product-based research encompasses the discovery, structure elucidation, biosynthesis, synthesis, and application of naturally occurring secondary metabolites. Securingine alkaloids, isolated from , have emerged as valuable molecular frameworks for exploring various aspects of natural product research due to their distinct chemical structures, characterized by unique oxidation and rearrangement patterns. Herein, we provide a comprehensive account of our journey in developing novel synthetic strategies and tactics for accessing all known and even unknown securingines and investigating the potential application of securingine B as a novel class of natural product-based molecular photoswitches.
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