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Rare diseases, defined by the 2002 Rare Disease Act, affect fewer than 5 in 10,000 individuals. Rare metabolic bone diseases (MBDs), such as osteogenesis imperfecta, hypophosphatasia, osteopetrosis, and other unclassified disorders, can disrupt bone development and remodeling, posing diagnostic and management challenges. This study analyzed data from the rarembd.
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ICPS, Pharmacovigilance & Clinical Research, Department of Biomedical and Clinical Sciences, University Hospital Luigi Sacco, Università Degli Studi di Milano, Milan, Italy.
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Perinatal mood and anxiety disorders (PMADs) are a spectrum of mental health conditions that are the most common pregnancy-related complications in the United States. Despite great strides in developing appropriate pharmacological and psychological treatments, PMADs continue to lack biological measures for diagnosis and prediction. Such measures could be effectively utilized to subtype and mechanistically explore PMADs and appropriately leverage mental healthcare resources.
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