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Open goals (eg, 'see how many steps you can reach today') have developed as a promising strategy for increasing physical activity and producing beneficial psychological outcomes such as autonomous motivation, enjoyment and confidence. However, it is not yet clear what the long-term outcomes of open goals are, what factors moderate their use or whether/how individuals transition away from open goals. Therefore, in this study ('Open to Move'), we aim to understand the mechanisms that explain why, when and for whom open goals are beneficial in promoting and maintaining physical activity. 'Open to Move' is a 12-month, exploratory, mixed-methods longitudinal study involving healthy adults aged 18-69 in Australia. Participants will receive a walking programme based on open goals via a mobile app and website, which will also provide feedback on their step counts and fortnightly one-to-one meetings online for the first 6 months. The outcomes will be measured using self-report surveys, interviews, recorded step counts on a mobile phone and process evaluation. The study is ongoing, and 81 participants have commenced thus far, with a target of 210 participants. We expect to conclude recruitment by August 2025 and anticipate that data collection will be completed by August 2026. This study will develop an understanding of the long-term outcomes of open goals, moderating factors and transitions to other goal types-providing important insights for developing a programme theory that can inform full-scale testing and implementation of open goals within physical activity interventions in future.
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http://dx.doi.org/10.1136/bmjsem-2025-002621 | DOI Listing |
J Coll Sci Teach
March 2025
RCSB Protein Data Bank, Institute for Quantitative Biomedicine, Rutgers University, Piscataway, New Jersey, United States.
Structure-function relationships are a core concept in many STEM disciplines. Most biology curricula introduce students to macromolecules, their building blocks, and other small molecules that play key roles in biological processes. However, the shapes, interactions, and functions of these molecules are often discussed using schematic diagrams, ignoring the vast amounts of three-dimensional structural and bioinformatics data freely available from public data resources.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Importance: Patients with advanced cancer frequently receive broad-spectrum antibiotics, but changing use patterns across the end-of-life trajectory remain poorly understood.
Objective: To describe the patterns of broad-spectrum antibiotic use across defined end-of-life intervals in patients with advanced cancer.
Design, Setting, And Participants: This nationwide, population-based, retrospective cohort study used data from the South Korean National Health Insurance Service database to examine broad-spectrum antibiotic use among patients with advanced cancer who died between July 1, 2002, and December 31, 2021.
Electromagn Biol Med
September 2025
Laboratory of Biophysics of Sub-Cellular Structures, Scientific-Research Institute of Biology, Chair of Biophysics, Faculty of Biology, Yerevan State University, Yerevan, Armenia.
Effect of millimeter range electromagnetic waves (MM EMW) with the frequency 51.8 GHz on the interaction of DNA-specific ligands-intercalators acridine orange (AO) and methylene blue (MB) with bovine serum albumin (BSA) has been studied. The measurements were implemented by the spectroscopic methods that open new opportunities for such goals.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, University of California Los Angeles, Los Angeles, USA.
This report discusses a case of a 33-year-old healthy woman who presented with upper extremity swelling and pain, which she attributed to an injury sustained during her work as a professional dancer. Given her persistent symptoms, she was eventually referred to the emergency room for evaluation of possible thrombosis. She was found to have an elevated D-dimer, and a CT angiogram of the chest revealed narrowing of the bilateral subclavian veins suggestive of venous thoracic outlet syndrome (VTOS).
View Article and Find Full Text PDFJAACAP Open
September 2025
University of Miami, Coral Gables, Florida.
Objective: Researchers have differentiated forms (overt, relational) and functions (proactive, reactive) of aggressive behavior; however, the assessment options for measuring these constructs in youth remain limited. This study examined the parent-report Peer Conflict Scale (PCS) for measuring forms and functions of youth aggressive behavior in English and Spanish, including short- and long-form versions.
Method: Participants were caregivers of 653 youths (ages 6-17; 57% male; 48% Hispanic) throughout North America.