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Article Abstract
Background: Schizophrenia may be diagnosed based on the presence of positive and negative symptoms. However, the underlying pathophysiology of these positive and negative symptoms remains poorly understood. In this study, we used resting-state functional connectivity (rsFC) to evaluate the integrity of neural circuits associated with primary and secondary rewards in first-episode schizophrenia (FES) and their relationship with positive and negative symptoms to better understand the physiological and pathological mechanisms of positive or negative symptoms.
Methods: A total of 109 patients with FES (34 with primary negative symptoms [PNS] and 75 with primary positive symptoms [PPS]) and 42 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging. The rsFC was assessed using a region-of-interest-based approach.
Results: Patients with FES exhibited reduced rsFC in neural circuits associated with both primary and secondary rewards, with greater reductions in those with PNS than in those with PPS. While PPS was associated with weaker rsFC than HCs, it did not correlate with symptom severity. Conversely, greater rsFC reductions were linked to more severe negative symptoms.
Conclusions: These findings suggest abnormal rsFC in neural circuits associated with both primary and secondary rewards in FES, with more pronounced impairments in PNS.
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| http://dx.doi.org/10.1016/j.ajp.2025.104477 | DOI Listing |
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