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Article Abstract
This retrospective study evaluated the efficacy and total cost of switching from filgrastim (Neupogen) to its biosimilar, filgrastim-aafi (Nivestym), for allogeneic peripheral blood stem cell collection (PBSCC). Among 127 donors, Nivestym and Neupogen showed comparable mobilization outcomes, achieving similar CD34 + cell counts and one-day collection success rates for ≥ 2.0 × 10⁶ and ≥ 4.0 × 10⁶ CD34 + cells/kg recipient weight. Nivestym offered significant reduction in total cost, with an average of $5171.92 versus $6288.76 (p < 0.0001). These findings support Nivestym as a viable alternative, highlighting the importance of evaluating both clinical outcomes and financial implications for biosimilar adoption.
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