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Article Abstract
We present an open-source code for 3D super-resolution ultrasound imaging. Open-3DULM was applied to transcranial imaging in habituated awake mice. Comparative analysis reveals that isoflurane anesthesia induces significant vasodilation and increased cerebral blood flow (CBF) in veins, while only a subset of arteries exhibits these effects compared to the awake state. This method could serve as a reference for developing new types of 3D vascular quantifications, particularly emphasizing the importance of awake and 3D imaging for accurate cerebral blood flow measurement in neuroscience research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144258 | PMC |
| http://dx.doi.org/10.1038/s44172-025-00415-4 | DOI Listing |
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